Journal article
The role of background synaptic noise in striatal fast spiking interneurons
Neurocomputing (Amsterdam), Vol.65, pp.727-732
06/01/2005
DOI: 10.1016/j.neucom.2004.10.068
Abstract
Striatal fast spiking (FS) interneurons provide inhibition to each other as well as to medium spiny projection (SP) neurons. They exhibit up-states synchronously with SP neurons, and receive GABAergic and AMPA synaptic input during both up- and down-states. The synaptic input during down-states can be considered noise and might affect detection of up-states. We investigate what role this background noise might play for up-state firing in a 127 compartment FS model neuron. The model has Na, KDr and KA conductances, and is activated through AMPA and GABA synapses. The model's response to current injection and synaptic inputs resembled experimental data. We show that intermediate levels of noise neither facilitates nor degrades the ability of the FS neuron model to detect up-states.
Details
- Title: Subtitle
- The role of background synaptic noise in striatal fast spiking interneurons
- Creators
- Jeanette Hellgren Kotaleski - KTH Royal Institute of TechnologyDietmar Plenz - National Institute of Mental HealthKim T. Blackwell - George Mason University
- Resource Type
- Journal article
- Publication Details
- Neurocomputing (Amsterdam), Vol.65, pp.727-732
- DOI
- 10.1016/j.neucom.2004.10.068
- ISSN
- 0925-2312
- eISSN
- 1872-8286
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 06/01/2005
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute
- Record Identifier
- 9984446414602771
Metrics
7 Record Views