Journal article
The role of basic leucine zipper transcription factor E4BP4 in the immune system and immune-mediated diseases
Clinical immunology (Orlando, Fla.), Vol.180, pp.5-10
07/2017
DOI: 10.1016/j.clim.2017.03.013
PMID: 28365317
Abstract
Basic leucine zipper transcription factor E4BP4 (also known as NFIL3) has been implicated in the molecular and cellular mechanisms of functions and activities in mammals. The interactions between E4BP4 and major regulators of cellular processes have triggered significant interest in the roles of E4BP4 in the pathogenesis of certain chronic diseases. Indeed, novel discoveries have been emerging to illustrate the involvement of E4BP4 in multiple disorders. It is recognized that E4BP4 is extensively involved in some immune-mediated diseases, but the mechanisms of E4BP4 involvement in these complex diseases remain poorly defined. Here we review the regulatory mechanisms of E4BP4 engaging in not only the biological function but also the development of immune-mediated diseases, paving the way for future therapies.
•E4BP4 is a basic leucine zipper transcription factor.•E4BP4 serves as a key regulator in the development and functions of immune cells.•E4BP4 plays a crucial role in various immune-mediated diseases.
Details
- Title: Subtitle
- The role of basic leucine zipper transcription factor E4BP4 in the immune system and immune-mediated diseases
- Creators
- Jinghua Yin - Department of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, No. 139, Renmin Road, Changsha 410011, ChinaJian Zhang - Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH43210, USAQianjin Lu - Department of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, No. 139, Renmin Road, Changsha 410011, China
- Resource Type
- Journal article
- Publication Details
- Clinical immunology (Orlando, Fla.), Vol.180, pp.5-10
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.clim.2017.03.013
- PMID
- 28365317
- ISSN
- 1521-6616
- eISSN
- 1521-7035
- Grant note
- DOI: 10.13039/501100001801, name: University of Western Australia; DOI: 10.13039/501100001809, name: National Natural Science Foundation of China, award: 81220108017, 81430074, 81301357, 30972745; DOI: 10.13039/100000002, name: National Institutes of Health, award: R01, AI090901, AI121196, AI123253; DOI: 10.13039/501100002822, name: Central South University, award: 2015zzts309
- Language
- English
- Date published
- 07/2017
- Academic Unit
- Pathology
- Record Identifier
- 9984046823202771
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