Journal article
The role of beta1 and beta2 adrenoceptors in isoproterenol-induced drinking
Brain research, Vol.656(1), pp.79-84
09/05/1994
DOI: 10.1016/0006-8993(94)91368-4
PMID: 7804848
Abstract
The present study examined the contribution of beta1 and beta2 adrenoceptor activation to drinking behavior and the stimulation of plasma renin activity produced by the mixed beta adrenoceptor agonist, isoproterenol. The stimulation of drinking by beta adrenoceptor activation could occur via two independent pathways; by either directly stimulating renal beta1 adrenoceptors on the juxtaglomerular cells to release renin or by stimulating vascular beta2 adrenoceptors that would decrease blood pressure and activate afferent neural and humoral mechanisms. Selective pharmacological antagonism of each adrenoceptor type was achieved by administering atenolol (2.5 mg/kg), a beta1 adrenoceptor antagonist, or ICI 118,551 (1 mg/kg), a beta2 adrenoceptor antagonist, before treatment with isoproterenol (25 micrograms/kg). Neither adrenoceptor mechanism alone could account for all of the water intake or stimulation of plasma renin activity due to isoproterenol treatment. Cardiovascular recordings confirmed the selectivity of the antagonists to their respective receptor subtypes, with atenolol blocking the beta1 adrenoceptor-mediated heart rate increases and ICI 118,551 blocking the beta 2 adrenoceptor-mediated depressor response to isoproterenol. The results provide evidence that the stimulation of both beta1 and beta2 adrenoceptors by isoproterenol acts in a synergistic manner to induce drinking and renin-angiotensin system activation.
Details
- Title: Subtitle
- The role of beta1 and beta2 adrenoceptors in isoproterenol-induced drinking
- Creators
- R F Kirby - Department of Psychology, University of Iowa, Iowa City 52242-1407C M NovakR L ThunhorstA K Johnson
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.656(1), pp.79-84
- DOI
- 10.1016/0006-8993(94)91368-4
- PMID
- 7804848
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Grant note
- HL 14338 / NHLBI NIH HHS HL 44536 / NHLBI NIH HHS
- Language
- English
- Date published
- 09/05/1994
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; University College Courses; Health and Human Physiology
- Record Identifier
- 9984213262502771
Metrics
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