Journal article
The role of fine-needle aspiration cytology in the evaluation of metastatic clear cell tumors
Cancer, Vol.87(6), pp.380-389
1999
DOI: 10.1002/(sici)1097-0142(19991225)87:6<380::aid-cncr9>3.0.co;2-1
PMID: 10603192
Abstract
Background: Clear cell tumors (CCTs) occur as primary neoplasms in a number of anatomic sites. Due to their overlapping morphologic features, these tumors can be challenging for the cytologist, particularly when they present as metastatic lesions.
Methods: Forty-nine fine-needle aspirations (FNA) of metastatic CCTs from 46 patients (age range, 29-87 years; mean, 64 years) were reviewed retrospectively. In addition to the routine smears and cell block preparations, ancillary studies were performed in selected cases. Clinical and/or histologic follow-up was obtained for all patients.
Results: The sites of the 49 FNAs were the lung (12 cases), lymph nodes (9 cases), liver (7 cases), bone (7 cases), soft tissue (4 cases), pelvis (2 cases), adrenal gland (2 cases), pancreas (1 case), thyroid (2 cases), peritoneum (2 cases), and vagina (1 case). Twenty-seven patients had a previous history of a CCT and the FNA material in these cases was consistent with a metastasis. The primary anatomic sites in these cases were the kidney (20 cases), ovary (2 cases), salivary gland (1 case), and cervix (1 case). On light microscopy, these tumors had a similar appearance and often were indistinguishable. Nineteen patients did not have a prior history of malignancy; 12 of these patients had a concurrent renal mass and the diagnosis of metastatic renal cell carcinoma was made. The anatomic site of origin of seven of the ten remaining tumors (kidney [2 cases], lung [2 cases], ovary [1 case], germ cell [1 case], and endometrium [1 case]) was established through immunocytochemical studies of cytologic material and clinical follow-up.
Conclusions: FNA plays an important role in the diagnosis of metastatic CCT. Cytologic examination, ancillary studies, and clinical information can establish the anatomic site of origin in the majority (95%) of cases, precluding the necessity of obtaining additional tissue.
Details
- Title: Subtitle
- The role of fine-needle aspiration cytology in the evaluation of metastatic clear cell tumors
- Creators
- J. H HUGHES - Department of Pathology, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, United StatesC. S JENSEN - Department of Pathology, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, United StatesA. D DONNELLY - Department of Pathology, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, United StatesM. B COHEN - Department of Pathology, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, United StatesJ. F SILVERMAN - Department of Pathology, Allegheny University of Health Sciences, Allegheny General Hospital Campus, Pittsburgh, Pennsylvania, United StatesK. R GEISINGER - Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United StatesS. S RAAB - Department of Pathology, Allegheny University of Health Sciences, Allegheny General Hospital Campus, Pittsburgh, Pennsylvania, United States
- Resource Type
- Journal article
- Publication Details
- Cancer, Vol.87(6), pp.380-389
- DOI
- 10.1002/(sici)1097-0142(19991225)87:6<380::aid-cncr9>3.0.co;2-1
- PMID
- 10603192
- NLM abbreviation
- Cancer
- ISSN
- 0008-543X
- eISSN
- 1097-0142
- Publisher
- Wiley-Liss; New York, NY
- Language
- English
- Date published
- 1999
- Academic Unit
- Pathology
- Record Identifier
- 9984047672102771
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