The role of glucocorticoid, interleukin-1β, and antioxidants in prenatal stress effects on embryonic microglia

Jada Bittle; Hanna E Stevens

doi:10.1186/s12974-018-1079-7

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The role of glucocorticoid, interleukin-1β, and antioxidants in prenatal stress effects on embryonic microglia

Journal article

Open access

Peer reviewed

The role of glucocorticoid, interleukin-1β, and antioxidants in prenatal stress effects on embryonic microglia

Jada Bittle and Hanna E Stevens

Journal of neuroinflammation, Vol.15(1), pp.44-44

02/16/2018

DOI: 10.1186/s12974-018-1079-7

PMCID: PMC5815231

PMID: 29452586

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https://doi.org/10.1186/s12974-018-1079-7View

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Abstract

Maternal stress during pregnancy is associated with an increased risk of psychopathology in offspring. Resident immune cells of the brain, microglia, may be mediators of prenatal stress and altered neurodevelopment. Here, we demonstrate that neither the exogenous pro-inflammatory cytokine, interleukin-1β (IL-1β), nor the glucocorticoid hormone, corticosterone, recapitulated the full effects of prenatal stress on the morphology of microglial cells in the cortical plate of embryonic mice; IL-1β effects showed greater similarity to prenatal stress effects on microglia. Unexpectedly, oil vehicle alone, which has antioxidant properties, moderated the effects of prenatal stress on microglia. Microglia changes with prenatal stress were also sensitive to the antioxidant, N-acetylcysteine, suggesting redox dysregulation as a mechanism of prenatal stress.

Microglia - metabolism

Microglia - drug effects

Prenatal Exposure Delayed Effects - prevention & control

Mice, Transgenic

Cerebral Cortex - diagnostic imaging

Cerebral Cortex - metabolism

Prenatal Exposure Delayed Effects - metabolism

Pregnancy

Antioxidants - therapeutic use

Animals

Cell Count - methods

Cerebral Cortex - embryology

Interleukin-1beta - toxicity

Female

Glucocorticoids - toxicity

Mice

Gene Knock-In Techniques - methods

Prenatal Exposure Delayed Effects - chemically induced

Details

Title: Subtitle: The role of glucocorticoid, interleukin-1β, and antioxidants in prenatal stress effects on embryonic microglia
Creators: Jada Bittle - Interdisciplinary Graduate Program in Neuroscience, University of Iowa, 356 Medical Research Center, Iowa City, IA, 52242, USA
Hanna E Stevens - Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, 2312 PBDB, 169 Newton Rd., Iowa City, IA, 52246, USA. hanna-stevens@uiowa.edu
Resource Type: Journal article
Publication Details: Journal of neuroinflammation, Vol.15(1), pp.44-44
DOI: 10.1186/s12974-018-1079-7
PMID: 29452586
PMCID: PMC5815231
NLM abbreviation: J Neuroinflammation
ISSN: 1742-2094
eISSN: 1742-2094
Publisher: England
Grant note: P30 ES005605 / NIEHS NIH HHS Award Program in Clinical Research / Robert E. Leet and Clara Guthrie Patterson Trust R25 MH077823 / NIMH NIH HHS NIMH K08 MH086812 / National Institute of Mental Health
Language: English
Date published: 02/16/2018
Academic Unit: Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
Record Identifier: 9984003984902771

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