The role of glutamate and GABA receptors in the generation of dorsal root reflexes by acute arthritis in the anaesthetized rat

H Rees; K A Sluka; K N Westlund; W D Willis

doi:10.1113/jphysiol.1995.sp020676

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The role of glutamate and GABA receptors in the generation of dorsal root reflexes by acute arthritis in the anaesthetized rat

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The role of glutamate and GABA receptors in the generation of dorsal root reflexes by acute arthritis in the anaesthetized rat

H Rees, K A Sluka, K N Westlund and W D Willis

The Journal of physiology, Vol.484(Pt 2), pp.437-445

04/15/1995

DOI: 10.1113/jphysiol.1995.sp020676

PMCID: PMC1157905

PMID: 7602536

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Abstract

1. In rats anaesthetized with pentobarbitone sodium, a unilateral acute arthritis was produced by the injection of kaolin and carrageenan into one knee-joint cavity. Four hours after injection, the medial articular nerve (MAN) was sectioned distally and recordings obtained from the proximal stump of the nerve. 2. Centrifugally conducted action potentials were recorded from the cut MAN following the development of arthritis. Acute dorsal rhizotomy, but not sympathectomy, prevented the action potentials, and so it is concluded that the action potentials represent dorsal root reflexes. 3. Central administration of either the GABAA receptor antagonist, bicuculline, or the non-NMDA receptor antagonist, CNQX, also prevented dorsal root reflexes in the MAN. 4. Neither the GABAB receptor antagonist, CGP35348, nor the NMDA receptor antagonist, AP7, altered the dorsal root reflexes in the MAN. 5. It is concluded that arthritis causes excess primary afferent depolarization in the dorsal horn of the spinal cord leading to dorsal root reflexes. It is proposed that these dorsal root reflexes contribute to the inflammation.

Details

Title: Subtitle: The role of glutamate and GABA receptors in the generation of dorsal root reflexes by acute arthritis in the anaesthetized rat
Creators: H Rees - Marine Biomedical Institute, UTMB, Galveston 77555, USA
K A Sluka - Marine Biomedical Institute, UTMB, Galveston 77555, USA
K N Westlund - Marine Biomedical Institute, UTMB, Galveston 77555, USA
W D Willis - Marine Biomedical Institute, UTMB, Galveston 77555, USA
Resource Type: Journal article
Publication Details: The Journal of physiology, Vol.484(Pt 2), pp.437-445
DOI: 10.1113/jphysiol.1995.sp020676
PMID: 7602536
PMCID: PMC1157905
NLM abbreviation: J Physiol
ISSN: 0022-3751
eISSN: 1469-7793
Language: English
Date published: 04/15/1995
Academic Unit: Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
Record Identifier: 9984040334002771

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