Journal article
The role of histone acetylation in memory formation and cognitive impairments
Neuropsychopharmacology (New York, N.Y.), Vol.38(1), pp.62-76
01/2013
DOI: 10.1038/npp.2012.86
PMCID: PMC3521994
PMID: 22669172
Abstract
Long-term memory formation requires transcription and protein synthesis. Over the past few decades, a great amount of knowledge has been gained regarding the molecular players that regulate the transcriptional program linked to memory consolidation. Epigenetic mechanisms have been shown to be essential for the regulation of neuronal gene expression, and histone acetylation has been one of the most studied and best characterized. In this review, we summarize the lines of evidence that have shown the relevance of histone acetylation in memory in both physiological and pathological conditions. Great advances have been made in identifying the writers and erasers of histone acetylation marks during learning. However, the identities of the upstream regulators and downstream targets that mediate the effect of changes in histone acetylation during memory consolidation remain restricted to a handful of molecules. We outline a general model by which corepressors and coactivators regulate histone acetylation during memory storage and discuss how the recent advances in high-throughput sequencing have the potential to radically change our understanding of how epigenetic control operates in the brain.
Details
- Title: Subtitle
- The role of histone acetylation in memory formation and cognitive impairments
- Creators
- Lucia Peixoto - Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USATed Abel
- Resource Type
- Journal article
- Publication Details
- Neuropsychopharmacology (New York, N.Y.), Vol.38(1), pp.62-76
- Publisher
- England
- DOI
- 10.1038/npp.2012.86
- PMID
- 22669172
- PMCID
- PMC3521994
- ISSN
- 0893-133X
- eISSN
- 1740-634X
- Grant note
- R01 MH087463 / NIMH NIH HHS T32 NS007413 / NINDS NIH HHS NS007413 / NINDS NIH HHS R01-MH087463 / NIMH NIH HHS
- Language
- English
- Date published
- 01/2013
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065731802771
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