Journal article
The role of hyperpolarized 129xenon in MR imaging of pulmonary function
European journal of radiology, Vol.86, pp.343-352
01/2017
DOI: 10.1016/j.ejrad.2016.09.015
PMCID: PMC5195899
PMID: 27707585
Abstract
•Recent advances in hyperpolarized 129Xe MRI are reviewed.•Xenon MRI allows for functional imaging of ventilation, diffusion, and gas exchange.•Xenon’s unique gas exchange imaging capabilities are highlighted.•Applications to obstructive and restrictive lung diseases are presented.•These advances are ready for translation to clinical applications.
In the last two decades, functional imaging of the lungs using hyperpolarized noble gases has entered the clinical stage. Both helium (3He) and xenon (129Xe) gas have been thoroughly investigated for their ability to assess both the global and regional patterns of lung ventilation. With advances in polarizer technology and the current transition towards the widely available 129Xe gas, this method is ready for translation to the clinic. Currently, hyperpolarized (HP) noble gas lung MRI is limited to selected academic institutions; yet, the promising results from initial clinical trials have drawn the attention of the pulmonary medicine community. HP 129Xe MRI provides not only 3-dimensional ventilation imaging, but also unique capabilities for probing regional lung physiology. In this review article, we aim to (1) provide a brief overview of current ventilation MR imaging techniques, (2) emphasize the role of HP 129Xe MRI within the array of different imaging strategies, (3) discuss the unique imaging possibilities with HP 129Xe MRI, and (4) propose clinical applications.
Details
- Title: Subtitle
- The role of hyperpolarized 129xenon in MR imaging of pulmonary function
- Creators
- Lukas Ebner - Duke UniversityJeff Kammerman - University of Wisconsin–MadisonBastiaan Driehuys - Duke UniversityMark L Schiebler - University of Wisconsin–MadisonRobert V Cadman - University of Wisconsin–MadisonSean B Fain - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- European journal of radiology, Vol.86, pp.343-352
- DOI
- 10.1016/j.ejrad.2016.09.015
- PMID
- 27707585
- PMCID
- PMC5195899
- NLM abbreviation
- Eur J Radiol
- ISSN
- 0720-048X
- eISSN
- 1872-7727
- Publisher
- Elsevier B.V
- Grant note
- DOI: 10.13039/100006775, name: GE Healthcare; DOI: 10.13039/100000050, name: NIH/NHLBI, award: R01 HL126771; DOI: 10.13039/100000050, name: NIH/NHLBI, award: U10 HL109168; DOI: 10.13039/100006775, name: GE Healthcare; DOI: 10.13039/501100001711, name: Swiss National Science Foundation; DOI: 10.13039/100000050, name: NIH/NHLBI, award: R01 HL105643
- Language
- English
- Date published
- 01/2017
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
- Record Identifier
- 9984274958802771
Metrics
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