Journal article
The role of inflammatory cytokines in suicidal behavior: A systematic review
European neuropsychopharmacology, Vol.23(12), pp.1672-1686
12/2013
DOI: 10.1016/j.euroneuro.2013.06.002
PMID: 23896009
Abstract
There is growing evidence that inflammatory mediators play a critical role in the pathophysiology of both major depression and suicidal behavior. Immunological differences have been reported in both major affective disorders and suicidal behavior. Specifically, increased levels of pro-inflammatory cytokines have been shown to correlate with the severity of depression and various cytokines have been identified as potentially important in understanding the pathophysiology of major affective disorders/suicidality. We aimed to conduct a systematic review of the current literature to investigate the association between inflammatory cytokines and suicidal behavior. Only articles from peer-reviewed journals were selected for inclusion in the present review. Most studies documented the association between suicidality and IL2, IL-6, IL-8, TNF-α and VEGF levels that have been found altered in suicidal behavior. The presence of major depressive disorder (MDD) with suicidal ideation/attempts was associated with differences in inflammatory cytokine profile when compared to that without suicidal ideation/attempts. Most suicide attempters or subjects with suicidal ideation showed an imbalance of the immune system but this does not imply the existence of a causal link. Also, not all studies demonstrated a positive correlation between inflammatory cytokines and suicidal behavior. Further additional studies should elucidate the molecular mechanisms of the immune activation pathways underlying suicidality.
Details
- Title: Subtitle
- The role of inflammatory cytokines in suicidal behavior: A systematic review
- Creators
- Gianluca Serafini - Department of Neurosciences, Mental Health and Sensory Organs—Suicide Prevention Center, Sapienza University of Rome, Sant'Andrea Hospital, 1035-1039 Via di Grottarossa, Rome 00189, ItalyMaurizio Pompili - Department of Neurosciences, Mental Health and Sensory Organs—Suicide Prevention Center, Sapienza University of Rome, Sant'Andrea Hospital, 1035-1039 Via di Grottarossa, Rome 00189, ItalyMaria Elena Seretti - Department of Neurosciences, Mental Health and Sensory Organs—Suicide Prevention Center, Sapienza University of Rome, Sant'Andrea Hospital, 1035-1039 Via di Grottarossa, Rome 00189, ItalyHenry Stefani - Department of Neurosciences, Mental Health and Sensory Organs—Suicide Prevention Center, Sapienza University of Rome, Sant'Andrea Hospital, 1035-1039 Via di Grottarossa, Rome 00189, ItalyMario Palermo - Department of Neurosciences, Mental Health and Sensory Organs—Suicide Prevention Center, Sapienza University of Rome, Sant'Andrea Hospital, 1035-1039 Via di Grottarossa, Rome 00189, ItalyWilliam Coryell - Department of Psychiatry, University of Iowa, Carver College of Medicine, 500 N Road, Iowa City, IA 52231-1190, United StatesPaolo Girardi - Department of Neurosciences, Mental Health and Sensory Organs—Suicide Prevention Center, Sapienza University of Rome, Sant'Andrea Hospital, 1035-1039 Via di Grottarossa, Rome 00189, Italy
- Resource Type
- Journal article
- Publication Details
- European neuropsychopharmacology, Vol.23(12), pp.1672-1686
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.euroneuro.2013.06.002
- PMID
- 23896009
- ISSN
- 0924-977X
- eISSN
- 1873-7862
- Language
- English
- Date published
- 12/2013
- Academic Unit
- Psychiatry
- Record Identifier
- 9984003424202771
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