Journal article
The role of insulator elements in defining domains of gene expression
Current opinion in genetics & development, Vol.7(2), pp.242-248
1997
DOI: 10.1016/S0959-437X(97)80134-7
PMID: 9115431
Abstract
Insulators are naturally occurring DNA sequences that protect transgenes from genomic position effects, thereby establishing independent functional domains within the chromosome. Recent studies have focused on the identification of the
cis and
trans requirements for insulator activity. These experiments demonstrate that insulators contain multiple components that cooperate to confer their unique properties. Additionally, they suggest that the mechanism of insulation is related to that of enhancer function. Two models of insulator function can be considered: a domain boundary and a transcriptional decoy model.
Details
- Title: Subtitle
- The role of insulator elements in defining domains of gene expression
- Creators
- Pamela K Geyer - Department of Biochemistry, University of Iowa, College of Medicine, Iowa City, Iowa 52242, USA
- Resource Type
- Journal article
- Publication Details
- Current opinion in genetics & development, Vol.7(2), pp.242-248
- DOI
- 10.1016/S0959-437X(97)80134-7
- PMID
- 9115431
- NLM abbreviation
- Curr Opin Genet Dev
- ISSN
- 0959-437X
- eISSN
- 1879-0380
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 1997
- Academic Unit
- Obstetrics and Gynecology; Biochemistry and Molecular Biology
- Record Identifier
- 9984024549502771
Metrics
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