Journal article
The role of monocyte-lineage cells in human immunodeficiency virus persistence: mechanisms and progress
Wei sheng wu yu gan ran, Vol.6(3), pp.129-132
09/25/2011
PMCID: PMC3215397
PMID: 22091217
Abstract
Human immunodeficiency virus type 1 (HIV-1) persistence is a major barrier to the successful treatment and eradication of acquired immunodeficiency syndrome (AIDS). In addition to resting CD4(+) T cells, a significant long-lived compartment of HIV-1 infection in vivo includes blood monocytes and tissue macrophages. Studying HIV-1 persistence in monocyte-lineage cells is critical because these cells are important HIV-1 target cells in vivo. Monocyte-lineage cells, including monocytes, dendritic cells (DCs) and macrophages, play a significant role in HIV-1 infection and transmission. These cells have been implicated as viral reservoirs that facilitate HIV-1 latency and persistence. A better understanding of HIV-1 interactions with monocyte-lineage cells can potentially aid in the development of new approaches for intervention. This minireview highlights the latest advances in understanding the role of monocyte-lineage cells in HIV-1 persistence and emphasizes new insights into the mechanisms underlying viral persistence.
Details
- Title: Subtitle
- The role of monocyte-lineage cells in human immunodeficiency virus persistence: mechanisms and progress
- Creators
- Li Wu - Center for Retrovirus Research. Department of Veterinary Biosciences. The Ohio State University. Columbus, Ohio 43210, USA
- Resource Type
- Journal article
- Publication Details
- Wei sheng wu yu gan ran, Vol.6(3), pp.129-132
- Publisher
- China
- PMID
- 22091217
- PMCID
- PMC3215397
- ISSN
- 1673-6184
- Grant note
- R21 AI078762-03 / NIAID NIH HHS R21 AI078762 / NIAID NIH HHS R01 AI068493 / NIAID NIH HHS R01 AI068493-06 / NIAID NIH HHS
- Language
- English
- Date published
- 09/25/2011
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984001223402771
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