Journal article
The role of mononuclear phagocytes in Ebola virus infection
Journal of leukocyte biology, Vol.104(4), pp.717-727
10/2018
DOI: 10.1002/JLB.4RI0518-183R
PMID: 30095866
Abstract
The filovirus, Zaire Ebolavirus (EBOV), infects tissue macrophages (Mϕs) and dendritic cells (DCs) early during infection. Viral infection of both cells types is highly productive, leading to increased viral load. However, virus infection of these two cell types results in different consequences for cellular function. Infection of Mϕs stimulates the production of proinflammatory and immunomodulatory cytokines and chemokines, leading to the production of a cytokine storm, while simultaneously increasing tissue factor production and thus facilitating disseminated intravascular coagulation. In contrast, EBOV infection of DCs blocks DC maturation and antigen presentation rendering these cells unable to communicate with adaptive immune response elements. Details of the known interactions of these cells with EBOV are reviewed here. We also identify a number of unanswered questions that remain about interactions of filoviruses with these cells.
Details
- Title: Subtitle
- The role of mononuclear phagocytes in Ebola virus infection
- Creators
- Kai J Rogers - Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USAWendy Maury - Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Journal of leukocyte biology, Vol.104(4), pp.717-727
- DOI
- 10.1002/JLB.4RI0518-183R
- PMID
- 30095866
- ISSN
- 0741-5400
- eISSN
- 1938-3673
- Grant note
- T32 GM067795 / NIGMS NIH HHS 2T32 GM067795-14 / University of Iowa Department of Microbiology and Immunology Development Award
- Language
- English
- Date published
- 10/2018
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984083874102771
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