Journal article
The role of neurotrophic factors in autism
Molecular psychiatry, Vol.16(5), pp.478-490
05/2011
DOI: 10.1038/mp.2010.103
PMID: 20938434
Abstract
Autism spectrum disorders (ASDs) are pervasive developmental disorders that frequently involve a triad of deficits in social skills, communication and language. For the underlying neurobiology of these symptoms, disturbances in neuronal development and synaptic plasticity have been discussed. The physiological development, regulation and survival of specific neuronal populations shaping neuronal plasticity require the so-called 'neurotrophic factors' (NTFs). These regulate cellular proliferation, migration, differentiation and integrity, which are also affected in ASD. Therefore, NTFs have gained increasing attention in ASD research. This review provides an overview and explores the key role of NTFs in the aetiology of ASD. We have also included evidence derived from neurochemical investigations, gene association studies and animal models. By focussing on the role of NTFs in ASD, we intend to further elucidate the puzzling aetiology of these conditions.
Details
- Title: Subtitle
- The role of neurotrophic factors in autism
- Creators
- T Nickl-Jockschat - Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, GermanyT M Michel
- Resource Type
- Journal article
- Publication Details
- Molecular psychiatry, Vol.16(5), pp.478-490
- DOI
- 10.1038/mp.2010.103
- PMID
- 20938434
- NLM abbreviation
- Mol Psychiatry
- ISSN
- 1476-5578
- eISSN
- 1476-5578
- Publisher
- England
- Language
- English
- Date published
- 05/2011
- Academic Unit
- Psychiatry; Neuroscience and Pharmacology
- Record Identifier
- 9984003999802771
Metrics
21 Record Views