Journal article
The role of neurotrophic factors in regulating the development of inner ear innervation
Trends in neurosciences (Regular ed.), Vol.20(4), pp.159-164
1997
DOI: 10.1016/S0166-2236(96)01007-7
PMID: 9106356
Abstract
Several neurotrophins and their receptors regulate the survival of vestibular and cochlear neurons and probably also the efferent and autonomic neurons that innervate the inner ear. Mice lacking either brain-derived neurotrophic factor (BDNF) or its associated receptor, TrkB, lose all innervation to the semicircular canals and have reduced innervation of the outer hair cells in the apical and middle turns of the cochlea. Mice lacking neurotrophin-3 (NT-3) or its receptor,TrkC, lose many spiral ganglion cells predominantly in the basal turn of the cochlea. Nerve fibers from spiral ganglion cells in the middle turn extend to inner hair cells of the base. In mice lacking both BDNF and NT-3, or both TrkB and TrkC, there is a complete loss of innervation to the inner ear. Thus, these two neurotrophins and their associated receptors have been shown to be absolutely necessary for the normal development of afferent innervation of the inner ear. Current research efforts are testing the therapeutic potential for neurotrophins to treat hearing loss.
Details
- Title: Subtitle
- The role of neurotrophic factors in regulating the development of inner ear innervation
- Creators
- B Fritzsch - Creighton University, Dept of Biomedical Sciences, Omaha, NE 68178, USAI Silos-Santiago - Bristol-Meyers Squibb, Dept of Molecular Oncology, Princeton, NJ 08543, USAL.M Bianchi - Medical University of South Carolina, Dept of Otolaryngology, Charleston, SC 29425, USAI Fariñas - Howard Hughes Medical Institute, UCLA, San Francisco, CA 94143, USA
- Resource Type
- Journal article
- Publication Details
- Trends in neurosciences (Regular ed.), Vol.20(4), pp.159-164
- DOI
- 10.1016/S0166-2236(96)01007-7
- PMID
- 9106356
- NLM abbreviation
- Trends Neurosci
- ISSN
- 0166-2236
- eISSN
- 1878-108X
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 1997
- Academic Unit
- Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
- Record Identifier
- 9984070654102771
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