The role of neutrophils and TNF-related apoptosis-inducing ligand (TRAIL) in bacillus Calmette–Guérin (BCG) immunotherapy for urothelial carcinoma of the bladder

Henry Rosevear; Andrew Lightfoot; Michael O’Donnell; Thomas Griffith

doi:10.1007/s10555-009-9195-6

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The role of neutrophils and TNF-related apoptosis-inducing ligand (TRAIL) in bacillus Calmette–Guérin (BCG) immunotherapy for urothelial carcinoma of the bladder

Journal article

Peer reviewed

The role of neutrophils and TNF-related apoptosis-inducing ligand (TRAIL) in bacillus Calmette–Guérin (BCG) immunotherapy for urothelial carcinoma of the bladder

Henry Rosevear, Andrew Lightfoot, Michael O’Donnell and Thomas Griffith

Cancer and metastasis reviews, Vol.28(3), pp.345-353

12/2009

DOI: 10.1007/s10555-009-9195-6

PMID: 19967427

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Abstract

Intravesical Mycobacterium bovis bacillus Calmette–Guérin (BCG) immunotherapy is a highly effective treatment for carcinoma in situ of the bladder, as well as high-risk nonmuscle invasive urothelial carcinoma of the bladder. Despite over 30 years of clinical experience with BCG, the therapy’s mechanism has remained enigmatic. Observations regarding the role of neutrophils in BCG immunotherapy have led to exciting discoveries regarding the potential role of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in creating the therapeutic benefit of BCG immunotherapy. In this paper, we will review the scope of the disease, highlight our understanding of the role for BCG in urothelial carcinoma of the bladder, explain the recent discoveries regarding the role of neutrophils and TRAIL in therapy, and theorize on potential future areas of research.

Biomedicine

TRAIL

BCG

Oncology

Cancer Research

Neutrophil

Urothelial carcinoma

Bladder cancer

Biomedicine general

Details

Title: Subtitle: The role of neutrophils and TNF-related apoptosis-inducing ligand (TRAIL) in bacillus Calmette–Guérin (BCG) immunotherapy for urothelial carcinoma of the bladder
Creators: Henry Rosevear - Department of Urology University of Iowa 375 Newton Road 3204 MERF Iowa City IA 52242-1089 USA
Andrew Lightfoot - Department of Urology University of Iowa 375 Newton Road 3204 MERF Iowa City IA 52242-1089 USA
Michael O’Donnell - Department of Urology University of Iowa 375 Newton Road 3204 MERF Iowa City IA 52242-1089 USA
Thomas Griffith - Department of Urology University of Iowa 375 Newton Road 3204 MERF Iowa City IA 52242-1089 USA
Resource Type: Journal article
Publication Details: Cancer and metastasis reviews, Vol.28(3), pp.345-353
Publisher: Springer US; Boston
DOI: 10.1007/s10555-009-9195-6
PMID: 19967427
ISSN: 0167-7659
eISSN: 1573-7233
Language: English
Date published: 12/2009
Academic Unit: Urology
Record Identifier: 9984051575402771

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