The role of osteocytes in targeted bone remodeling: a mathematical model

Jason M Graham; Bruce P Ayati; Sarah A Holstein; James A Martin

doi:10.1371/journal.pone.0063884

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The role of osteocytes in targeted bone remodeling: a mathematical model

Journal article

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Peer reviewed

The role of osteocytes in targeted bone remodeling: a mathematical model

Jason M Graham, Bruce P Ayati, Sarah A Holstein and James A Martin

PloS one, Vol.8(5), pp.e63884-e63884

2013

DOI: 10.1371/journal.pone.0063884

PMCID: PMC3661588

PMID: 23717504

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Abstract

Until recently many studies of bone remodeling at the cellular level have focused on the behavior of mature osteoblasts and osteoclasts, and their respective precursor cells, with the role of osteocytes and bone lining cells left largely unexplored. This is particularly true with respect to the mathematical modeling of bone remodeling. However, there is increasing evidence that osteocytes play important roles in the cycle of targeted bone remodeling, in serving as a significant source of RANKL to support osteoclastogenesis, and in secreting the bone formation inhibitor sclerostin. Moreover, there is also increasing interest in sclerostin, an osteocyte-secreted bone formation inhibitor, and its role in regulating local response to changes in the bone microenvironment. Here we develop a cell population model of bone remodeling that includes the role of osteocytes, sclerostin, and allows for the possibility of RANKL expression by osteocyte cell populations. We have aimed to give a simple, yet still tractable, model that remains faithful to the underlying system based on the known literature. This model extends and complements many of the existing mathematical models for bone remodeling, but can be used to explore aspects of the process of bone remodeling that were previously beyond the scope of prior modeling work. Through numerical simulations we demonstrate that our model can be used to explore theoretically many of the qualitative features of the role of osteocytes in bone biology as presented in recent literature.

Models, Theoretical

Bone Morphogenetic Proteins - metabolism

Osteogenesis - physiology

Bone and Bones - physiology

RANK Ligand - metabolism

Osteocytes - metabolism

Osteoblasts - physiology

Bone Remodeling - physiology

Osteoclasts - physiology

Cell Differentiation - physiology

Osteocytes - physiology

Details

Title: Subtitle: The role of osteocytes in targeted bone remodeling: a mathematical model
Creators: Jason M Graham - Department of Mathematics, University of Scranton, Scranton, Pennsylvania, USA. jason.grahamscranton.edu
Bruce P Ayati
Sarah A Holstein
James A Martin
Resource Type: Journal article
Publication Details: PloS one, Vol.8(5), pp.e63884-e63884
DOI: 10.1371/journal.pone.0063884
PMID: 23717504
PMCID: PMC3661588
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Publisher: United States
Grant note: 1 P50 AR055533 / NIAMS NIH HHS P50 AR055533 / NIAMS NIH HHS
Language: English
Date published: 2013
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Orthopedics and Rehabilitation; Mathematics
Record Identifier: 9983985891202771

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