The role of oxidative stress and NADPH oxidase in cerebrovascular disease

Sophocles Chrissobolis; Frank M Faraci

doi:10.1016/j.molmed.2008.09.003

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The role of oxidative stress and NADPH oxidase in cerebrovascular disease

Journal article

Open access

Peer reviewed

The role of oxidative stress and NADPH oxidase in cerebrovascular disease

Sophocles Chrissobolis and Frank M Faraci

Trends in molecular medicine, Vol.14(11), pp.495-502

11/2008

DOI: 10.1016/j.molmed.2008.09.003

PMCID: PMC3140460

PMID: 18929509

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Abstract

The study of reactive oxygen species (ROS) and oxidative stress remains a very active area of biological research, particularly in relation to cellular signaling and the role of ROS in disease. In the cerebral circulation, oxidative stress occurs in diverse forms of disease and with aging. Within the vessel wall, ROS produce complex structural and functional changes that have broad implications for regulation of cerebral perfusion and permeability of the blood-brain barrier. These oxidative-stress-induced changes are thought to contribute to the progression of cerebrovascular disease. Here, we highlight recent findings in relation to oxidative stress in the cerebral vasculature, with an emphasis on the emerging role for NADPH oxidases as a source of ROS and the role of ROS in models of disease.

Animals

Reactive Oxygen Species - metabolism

Oxidative Stress

Humans

Cerebrovascular Disorders - enzymology

NADPH Oxidases - metabolism

NADPH Oxidases - genetics

Cerebrovascular Disorders - metabolism

Disease Models, Animal

Details

Title: Subtitle: The role of oxidative stress and NADPH oxidase in cerebrovascular disease
Creators: Sophocles Chrissobolis - Departments of Internal Medicine and Pharmacology, Division of Cardiovascular Diseases, Cardiovascular Center, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
Frank M Faraci
Resource Type: Journal article
Publication Details: Trends in molecular medicine, Vol.14(11), pp.495-502
DOI: 10.1016/j.molmed.2008.09.003
PMID: 18929509
PMCID: PMC3140460
NLM abbreviation: Trends Mol Med
ISSN: 1471-4914
eISSN: 1471-499X
Publisher: England
Grant note: R01 HL038901 / NHLBI NIH HHS P01 NS024621 / NINDS NIH HHS P01 NS024621-20 / NINDS NIH HHS HL-38901 / NHLBI NIH HHS NS-24621 / NINDS NIH HHS P01 HL062984 / NHLBI NIH HHS HL-62984 / NHLBI NIH HHS R01 HL038901-20 / NHLBI NIH HHS
Language: English
Date published: 11/2008
Academic Unit: Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040586202771

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