Journal article
The role of the T-cell costimulatory molecule Tim-1 in the immune response
Immunologic research, Vol.39(1-3), pp.52-61
01/01/2007
DOI: 10.1007/s12026-007-0063-6
PMID: 17917055
Abstract
Upon encountering antigen, CD4+ T-cells become activated and can differentiate into subsets with distinct functional characteristics. One of these subsets is the Th2 cell, which generates large amounts of interleukin (IL)-4, -5, -10 and -13 in response to a subsequent encounter with antigen. In the context of a protective immune response, Th2 cells promote immune cell activation, antibody production, and inflammatory responses that help clear infections. However, aberrant responses by Th2 cells can lead to debilitating allergic diseases such as asthma. Thus, a reasonable approach toward gaining novel insights into immunity and allergic disease is to define the mechanisms that control Th2 cell differentiation and mature Th2 cell function. Recent work suggests that a protein called Tim-1 ((T) under bar -cell (i) under bar mmunoglobulin and (m) under bar ucin protein-1) is expressed oil CD4+ T-cells and plays a central role in regulating Th2 responses. Genetic analysis has linked polymorphisms in the human TIM1 gene to susceptibility to allergic disease, while studies involving mice have shown that ligation of Tim-1 promotes CD4+ T-cell activation. The signal transduction pathways downstream of Tim-1 are a relatively unexplored area. Continued study will undoubtedly reveal novel insights regarding the relationships between Tim-1, Th2 responses, and allergic disease.
Details
- Title: Subtitle
- The role of the T-cell costimulatory molecule Tim-1 in the immune response
- Creators
- Miranda Curtiss - Immunology Graduate ProgramJohn Colgan - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Immunologic research, Vol.39(1-3), pp.52-61
- Publisher
- Humana Press Inc
- DOI
- 10.1007/s12026-007-0063-6
- PMID
- 17917055
- ISSN
- 0257-277X
- eISSN
- 1559-0755
- Number of pages
- 10
- Grant note
- R01AI067489 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) T32 GM007337 / NIGMS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) R01 AI067489 / NIAID NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) T32GM007337 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Language
- English
- Date published
- 01/01/2007
- Academic Unit
- Anatomy and Cell Biology; Immunology; Internal Medicine
- Record Identifier
- 9984284357702771
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