The role of the cerebellum in schizophrenia

Nancy C Andreasen; Ronald Pierson

doi:10.1016/j.biopsych.2008.01.003

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The role of the cerebellum in schizophrenia

Journal article

Open access

Peer reviewed

The role of the cerebellum in schizophrenia

Nancy C Andreasen and Ronald Pierson

Biological psychiatry (1969), Vol.64(2), pp.81-88

07/15/2008

DOI: 10.1016/j.biopsych.2008.01.003

PMCID: PMC3175494

PMID: 18395701

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Abstract

For many years the cerebellum has been considered to serve as a coordinator of motor function. Likewise, for many years schizophrenia has been considered to be a disease that primarily affects the cerebrum. This review summarizes recent evidence that both these views must be revised in the light of emerging evidence about cerebellar function and the mechanisms of schizophrenia. Evidence indicating that the cerebellum plays a role in higher cortical functions is summarized. Evidence indicating that cerebellar abnormalities occur in schizophrenia is also reviewed. These suggest interesting directions for future research.

Cognition Disorders - physiopathology

Pons - physiopathology

Humans

Cerebellum - physiopathology

Positron-Emission Tomography

Schizophrenic Psychology

Psychomotor Performance - physiology

Cerebral Cortex - physiopathology

Neuropsychological Tests

Psychiatric Status Rating Scales

Thalamus - physiopathology

Schizophrenia - physiopathology

Brain Mapping

Long-Term Potentiation - physiology

Olivary Nucleus - physiopathology

Nerve Net - physiopathology

Higher Nervous Activity - physiology

Cognition Disorders - psychology

Details

Title: Subtitle: The role of the cerebellum in schizophrenia
Creators: Nancy C Andreasen - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA. nancy-andreasen@uiowa.edu
Ronald Pierson
Resource Type: Journal article
Publication Details: Biological psychiatry (1969), Vol.64(2), pp.81-88
DOI: 10.1016/j.biopsych.2008.01.003
PMID: 18395701
PMCID: PMC3175494
NLM abbreviation: Biol Psychiatry
ISSN: 0006-3223
eISSN: 1873-2402
Publisher: United States
Grant note: 5 R01 MH 04856-20 / NIMH NIH HHS R01 MH040856-21 / NIMH NIH HHS 5 R01 MH060990-09 / NIMH NIH HHS R01 MH060990 / NIMH NIH HHS R01 MH040856 / NIMH NIH HHS
Language: English
Date published: 07/15/2008
Academic Unit: Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984004093302771

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