Journal article
The role of ubiquitin-proteasome system in glioma survival and growth
Growth factors (Chur, Switzerland), Vol.31(3), pp.106-113
06/01/2013
DOI: 10.3109/08977194.2013.799156
PMID: 23688106
Abstract
High-grade gliomas represent a group of aggressive brain tumors with poor prognosis due to an inherent capacity of persistent cell growth and survival. The ubiquitin-proteasome system (UPS) is an intracellular machinery responsible for protein turnover. Emerging evidence implicates various proteins targeted for degradation by the UPS in key survival and proliferation signaling pathways of these tumors. In this review, we discuss the involvement of UPS in the regulation of several mediators and effectors of these pathways in malignant gliomas.
Details
- Title: Subtitle
- The role of ubiquitin-proteasome system in glioma survival and growth
- Creators
- Panagiotis J. Vlachostergios - University of ThessalyIoannis A. Voutsadakis - Charmo UniversityChristos N. Papandreou - University of Thessaly
- Resource Type
- Journal article
- Publication Details
- Growth factors (Chur, Switzerland), Vol.31(3), pp.106-113
- Publisher
- Taylor & Francis
- DOI
- 10.3109/08977194.2013.799156
- PMID
- 23688106
- ISSN
- 0897-7194
- eISSN
- 1029-2292
- Number of pages
- 8
- Language
- English
- Date published
- 06/01/2013
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806602402771
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