Journal article
The role of vimentin expression in predicting the long-term outcome of patients with localized renal cell carcinoma
British journal of urology, Vol.80(6), pp.864-868
1997
DOI: 10.1046/j.1464-410X.1997.00489.x
PMID: 9439398
Abstract
Objective. To evaluate the prognostic significance of vimentin intermediary filament expression by tumour cells in patients with renal cell carcinoma (RCC) localized to the kidney. Patients and methods. Thirty-nine patients with localized RCC (pT1,pT2) were assessed in a retrospective study. Tumour cells were evaluated immunohistochemically for vimentin, epithelial membrane antigen (EMA) and polyclonal cytokeratin expression. The prognosis of cases expressing positive vimentin expression in tumour cells was compared with that of cases with no expression. Additional clinical information and conventional histological grade of the tumours were also included in the survival analysis. Results. Univariate analysis of patient survival and tumour recurrence showed a statistically significant association between vimentin-positive tumours and poor patient outcome; the EMA stain showed borderline significance and histological grade was significantly associated with prognosis. The combination of tumour vimentin expression and histological grade provided a better predictor of prognosis and proved to be the best independent prognosticator of survival by multivariate analysis. Conclusions. Vimentin expression by tumour cells provides important prognostic information for patients with localized RCC; the combination of vimentin expression and histological grade is a better predictor for survival than grade or vimentin expression alone.
Details
- Title: Subtitle
- The role of vimentin expression in predicting the long-term outcome of patients with localized renal cell carcinoma
- Creators
- E Sabo - Bnai Zion Medical CenterI Miselevich - Bnai Zion Medical CenterJ Bejar - Bnai Zion Medical CenterM Segenreich - Bnai Zion Medical CenterM Wald - Bnai Zion Medical CenterB Moskovitz - Bnai Zion Medical CenterO Nativ - Bnai Zion Medical Center
- Resource Type
- Journal article
- Publication Details
- British journal of urology, Vol.80(6), pp.864-868
- Publisher
- Blackwell
- DOI
- 10.1046/j.1464-410X.1997.00489.x
- PMID
- 9439398
- ISSN
- 0007-1331
- eISSN
- 1464-410X
- Language
- English
- Date published
- 1997
- Academic Unit
- Urology
- Record Identifier
- 9984320063602771
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