Journal article
The roles of NFE2L1 in adipocytes: Structural and mechanistic insight from cell and mouse models
Redox biology, Vol.44, pp.102015-102015
08/01/2021
DOI: 10.1016/j.redox.2021.102015
PMCID: PMC8170497
PMID: 34058615
Abstract
Adipocytes play pivotal roles in maintaining energy homeostasis by storing lipids in adipose tissue (AT), regulating the flux of lipids between AT and the circulation in response to the body's energy requirements and secreting a variety of hormones, cytokines and other factors. Proper AT development and function ensure overall metabolic health. Nuclear factor erythroid 2-related factor 1 (NFE2L1, also known as NRF1) belongs to the CNCbZIP family and plays critical roles in regulating a wide range of essential cellular functions and varies stress responses in many cells and tissues. Human and rodent Nfe2l1 genes can be transcribed into multiple splice variants resulting in various protein isoforms, which may be further modified by a variety of post-translational mechanisms. While the long isoforms of NFE2L1 have been established as master regulators of cellular adaptive antioxidant response and proteasome homeostasis, the exact tissue distribution and physiological function of NFE2L1 isoforms, the short isoforms in particular, are still under intense investigation. With regard to key roles of NFE2L1 in adipocytes, emerging data indicates that deficiency of Nfe2l1 results in aberrant adipogenesis and impaired AT functioning. Intriguingly, a single nucleotide polymorphism (SNP) of the human NFE2L1 gene is associated with obesity. In this review, we summarize the most significant findings regarding the specific roles of the multiple isoforms of NFE2L1 in AT formation and function. We highlight that NFE2L1 plays a fundamental regulatory role in the expression of multiple genes that are crucial to AT metabolism and function and thus could be an important target to improve disease states involving aberrant adipose plasticity and lipid homeostasis.
Details
- Title: Subtitle
- The roles of NFE2L1 in adipocytes: Structural and mechanistic insight from cell and mouse models
- Creators
- Suping Ren - China Medical UniversityYiying Bian - China Medical UniversityYongyong Hou - China Medical UniversityZhendi Wang - China Medical UniversityZhuo Zuo - China Medical UniversityZhiyuan Liu - China Medical UniversityYue Teng - Harbin Medical UniversityJingqi Fu - China Medical UniversityHuihui Wang - China Medical UniversityYuanyuan Xu - China Medical UniversityQiang Zhang - Emory UniversityYanyan Chen - China Medical UniversityJingbo Pi - China Medical University
- Resource Type
- Journal article
- Publication Details
- Redox biology, Vol.44, pp.102015-102015
- DOI
- 10.1016/j.redox.2021.102015
- PMID
- 34058615
- PMCID
- PMC8170497
- NLM abbreviation
- Redox Biol
- ISSN
- 2213-2317
- eISSN
- 2213-2317
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- 2019JH8/10300012 / Liaoning Key Research and Development Guidance Plan 81830099; 82020108027; 81400839; 82022063; 81402661; 81573106; 82073513; 82003500; 81402635 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) YJ20190263 / China Postdoctoral Management Foundation 2018YFC1311600 / National Key R&D Program of China
- Language
- English
- Date published
- 08/01/2021
- Academic Unit
- Neurology
- Record Identifier
- 9984303022702771
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