Journal article
The roles of cutaneous lipids in host defense
Biochimica et biophysica acta. Molecular and cell biology of lipids, Vol.1841(3), pp.319-322
03/2014
DOI: 10.1016/j.bbalip.2013.08.012
PMCID: PMC3943473
PMID: 23994607
Abstract
Lauric acid (C12:0) and sapienic acid (C16:1Δ6) derived from human sebaceous triglycerides are potent antimicrobials found at the human skin surface. Long-chain bases (sphingosine, dihydrosphingosine and 6-hydroxysphingosine) are also potent and broad-acting antimicrobials normally present at the skin surface. These antimicrobials are generated through the action of ceramidases on ceramides from the stratum corneum. These natural antimicrobials are thought to be part of the innate immune system of the skin. Exogenously providing these lipids to the skin may provide a new therapeutic option, or could potentially provide prophylaxis in people at risk of infection. This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier. Guest Editors: Kenneth R. Feingold and Peter Elias.
•Sphingoid bases, and certain fatty acids are antimicrobials at the skin surface.•Long-chain bases are derived from ceramides through the action of ceramidases.•The antimicrobial fatty acids are derived from sebaceous triglycerides.•The activities of antimicrobial lipids vary with the microbe.
Details
- Title: Subtitle
- The roles of cutaneous lipids in host defense
- Creators
- Carol L. Fischer - University of IowaDerek R. Blanchette - University of IowaKim A. Brogden - University of IowaDeborah V. Dawson - University of IowaDavid R. Drake - Dows Institute, University of Iowa, Iowa City, IA, USAJennifer R. Hill - Augusta UniversityPhilip W. Wertz - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Biochimica et biophysica acta. Molecular and cell biology of lipids, Vol.1841(3), pp.319-322
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.bbalip.2013.08.012
- PMID
- 23994607
- PMCID
- PMC3943473
- ISSN
- 1388-1981
- eISSN
- 1879-2618
- Language
- English
- Date published
- 03/2014
- Academic Unit
- Oral Pathology, Radiology and Medicine; Endodontics; Biostatistics; Pediatric Dentistry; Dental Research; Periodontics
- Record Identifier
- 9984367744802771
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