Journal article
The roles of molecular chaperones in regulating cell metabolism
FEBS letters, Vol.597(13), pp.1681-1701
07/2023
DOI: 10.1002/1873-3468.14682
PMCID: PMC10984649
PMID: 37287189
Abstract
Fluctuations in nutrient and biomass availability, often as a result of disease, impart metabolic challenges that must be overcome in order to sustain cell survival and promote proliferation. Cells adapt to these environmental changes and stresses by adjusting their metabolic networks through a series of regulatory mechanisms. Our understanding of these rewiring events has largely been focused on those genetic transformations that alter protein expression and the biochemical mechanisms that change protein behavior, such as post-translational modifications and metabolite-based allosteric modulators. Mounting evidence suggests that a class of proteome surveillance proteins called molecular chaperones also can influence metabolic processes. Here, we summarize several ways the Hsp90 and Hsp70 chaperone families act on human metabolic enzymes and their supramolecular assemblies to change enzymatic activities and metabolite flux. We further highlight how these chaperones can assist in the translocation and degradation of metabolic enzymes. Collectively, these studies provide a new view for how metabolic processes are regulated to meet cellular demand and inspire new avenues for therapeutic intervention.
Details
- Title: Subtitle
- The roles of molecular chaperones in regulating cell metabolism
- Creators
- Matthew J. Binder - Pennsylvania State UniversityAnthony M. Pedley - Pennsylvania State University
- Resource Type
- Journal article
- Publication Details
- FEBS letters, Vol.597(13), pp.1681-1701
- DOI
- 10.1002/1873-3468.14682
- PMID
- 37287189
- PMCID
- PMC10984649
- NLM abbreviation
- FEBS Lett
- ISSN
- 0014-5793
- eISSN
- 1873-3468
- Publisher
- Wiley
- Number of pages
- 21
- Grant note
- Huck Institutes of the Life Sciences at The Pennsylvania State University
- Language
- English
- Date published
- 07/2023
- Academic Unit
- Biochemistry and Molecular Biology
- Record Identifier
- 9984771647902771
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