Journal article
The round window membrane following application of staphylococcal exotoxin: An electron microscopic study
The Laryngoscope, Vol.91(12), pp.2007-2017
12/1981
DOI: 10.1288/00005537-198112000-00003
PMID: 7321721
Abstract
The round window membrane has been considered as a pathway for the passage of toxic substances from the middle ear cavity to the vestibular labyrinth in cases of otitis media. To determine the role of the round window membrane in this passage, chinchillas were given intrabullar inoculations with staphylococcal exotoxin and the round window membranes were examined electron microscopically. We observed cytoplasmic vacuolization, intercellular edema, cellular and nuclear swelling of the surface epithelia and polymorphonuclear leukocyte (PMN) infiltration of the fibrous layer. Light microscopic observation of the labyrinth revealed PMN infiltration of the most basal portion of the scala tympani. These findings demonstrate a chemotactic effect of the toxin for PMNs and support the concept of the round window membrane as an important avenue of entry.
Details
- Title: Subtitle
- The round window membrane following application of staphylococcal exotoxin: An electron microscopic study
- Creators
- Patricia A SchachernMichael M PaparellaMarcos GoycooleaBurt GoldbergPatrick Schlievert
- Resource Type
- Journal article
- Publication Details
- The Laryngoscope, Vol.91(12), pp.2007-2017
- Publisher
- John Wiley & Sons, Inc; Hoboken, NJ
- DOI
- 10.1288/00005537-198112000-00003
- PMID
- 7321721
- ISSN
- 0023-852X
- eISSN
- 1531-4995
- Number of pages
- 11
- Grant note
- The National Institute of Neurological Communicative Disorders and Stroke Grants (#NS‐14538‐02 and NS04615)
- Language
- English
- Date published
- 12/1981
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001153802771
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