Journal article
The seasonal distribution of immune thrombotic thrombocytopenic purpura is influenced by geography: Epidemiologic findings from a multi‐center analysis of 719 disease episodes
American journal of hematology, Vol.99(11), pp.2063-2074
11/2024
DOI: 10.1002/ajh.27458
PMID: 39136282
Abstract
Abstract Prior studies have suggested that immune thrombotic thrombocytopenic purpura (iTTP) may display seasonal variation; however, methodologic limitations and sample sizes have diminished the ability to perform a rigorous assessment. This 5‐year retrospective study assessed the epidemiology of iTTP and determined whether it displays a seasonal pattern. Patients with both initial and relapsed iTTP (defined as a disintegrin and metalloprotease with thrombospondin type motifs 13 activity <10%) from 24 tertiary centers in Australia, Canada, France, Greece, Italy, Spain, and the US were included. Seasons were defined as: Northern Hemisphere—winter (December–February); spring (March–May); summer (June–August); autumn (September–November) and Southern Hemisphere—winter (June–August); spring (September–November); summer (December–February); autumn (March–May). Additional outcomes included the mean temperature in months with and without an iTTP episode at each site. A total of 583 patients experienced 719 iTTP episodes. The observed proportion of iTTP episodes during the winter was significantly greater than expected if equally distributed across seasons (28.5%, 205/719, 25.3%–31.9%; p = .03). Distance from the equator and mean temperature deviation both positively correlated with the proportion of iTTP episodes during winter. Acute iTTP episodes were associated with the winter season and colder temperatures, with a second peak during summer. Occurrence during winter was most pronounced at sites further from the equator and/or with greater annual temperature deviations. Understanding the etiologies underlying seasonal patterns of disease may assist in discovery and development of future preventative therapies and inform models for resource utilization.
Details
- Title: Subtitle
- The seasonal distribution of immune thrombotic thrombocytopenic purpura is influenced by geography: Epidemiologic findings from a multi‐center analysis of 719 disease episodes
- Creators
- Jeremy W. Jacobs - Mayo ClinicCaroline G. Stanek - University of Alabama at BirminghamGarrett S. Booth - Vanderbilt University Medical CenterArgiris Symeonidis - General University Hospital of PatrasAndrew W. Shih - University of British ColumbiaElizabeth S. Allen - University of California, San DiegoEleni Gavriilaki - G. Papanikolaou General HospitalBrenda J. Grossman - Washington University in St. LouisKaterina Pavenski - St. Michael's HospitalAmy Moorehead - St. Michael's HospitalFlora Peyvandi - Fondazione IRCCS Ca' Granda Ospedale Maggiore PoliclinicoPasquale Agosti - Fondazione IRCCS Ca' Granda Ospedale Maggiore PoliclinicoIlaria Mancini - Fondazione IRCCS Ca' Granda Ospedale Maggiore PoliclinicoLaura D. Stephens - University of California, San DiegoJay S. Raval - University of New MexicoMaria Eva Mingot-Castellano - Hospital Universitario Virgen del RocíoElizabeth P. Crowe - Johns Hopkins MedicineLaetitia Daou - Johns Hopkins MedicineMenaka Pai - McMaster UniversityDonald M. Arnold - McMaster UniversityMarisa B. Marques - University of Alabama at BirminghamRyan Henrie - University of British ColumbiaTyler W. Smith - University of British ColumbiaGayatri Sreenivasan - University of British ColumbiaRance C. Siniard - University of Alabama at BirminghamLisa R. Wallace - Washington University in St. LouisChisa Yamada - Michigan MedicineMiriam Andrea Duque - University of MiamiYanyun Wu - University of MiamiThomas J. Harrington - University of MiamiDiana M. Byrnes - University of MiamiAikaterini Bitsani - Laiko General Hospital of AthensAmanda K. Davis - The Alfred HospitalDanielle H. Robinson - The Alfred HospitalQuentin Eichbaum - Vanderbilt University Medical CenterCristina A. Figueroa Villalba - Yale School of MedicineJustin E. Juskewitch - Mayo ClinicGeorgia Kaiafa - AHEPA University HospitalEleni Kapsali - University of IoanninaEllen Klapper - Cedars-Sinai Medical CenterIngrid Perez-Alvarez - Cedars-Sinai Medical CenterMonica S. Klein - Mayo ClinicNikolaos Kotsiou - Aristotle University of ThessalonikiChrysavgi Lalayanni - G. Papanikolaou General HospitalEvdokia Mandala - Aristotle University of ThessalonikiFatima Aldarweesh - University of ChicagoRahaf Alkhateb - University of ChicagoLisandro Fortuny - VitalantZois Mellios - Evangelismos HospitalApostolia Papalexandri - G. Papanikolaou General HospitalMeredith G. Parsons - University of IowaAnnette J. Schlueter - University of IowaChristopher A. Tormey - Yale UniversityCameron Wellard - Monash UniversityErica M. Wood - Monash UniversityShiyang Jia - Monash UniversityAllison P. Wheeler - Vanderbilt University Medical CenterAmy A. Powers - Queen's Medical CenterChristopher B. Webb - The University of Texas Southwestern Medical CenterSean G. Yates - The University of Texas Southwestern Medical CenterRaïda Bouzid - Centre de Référence des Microangiopathies Thrombotiques (CNR‐MAT) AP‐HP Paris FrancePaul Coppo - Centre de Référence des Microangiopathies Thrombotiques (CNR‐MAT) AP‐HP Paris France, Service d'Hématologie, Hôpital Saint‐Antoine AP‐HP Paris FranceEvan M. Bloch - Johns Hopkins UniversityBrian D. Adkins - The University of Texas Southwestern Medical Center
- Resource Type
- Journal article
- Publication Details
- American journal of hematology, Vol.99(11), pp.2063-2074
- Publisher
- WILEY
- DOI
- 10.1002/ajh.27458
- PMID
- 39136282
- ISSN
- 0361-8609
- eISSN
- 1096-8652
- Language
- English
- Electronic publication date
- 08/13/2024
- Date published
- 11/2024
- Academic Unit
- Pathology
- Record Identifier
- 9984696808402771
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