The sequence of the Mycoplasma arthritidis superantigen, MAM: Identification functional domains and comparison with microbial superantigens and plant lectin mitogens

B Cole; K Knudtson; A Oliphant; A D Sawitzke; A Pole; M Manohar; L Benson; E Ahmed; C L Atkin

doi:10.1084/jem.183.3.1105

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The sequence of the Mycoplasma arthritidis superantigen, MAM: Identification functional domains and comparison with microbial superantigens and plant lectin mitogens

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The sequence of the Mycoplasma arthritidis superantigen, MAM: Identification functional domains and comparison with microbial superantigens and plant lectin mitogens

B Cole, K Knudtson, A Oliphant, A D Sawitzke, A Pole, M Manohar, L Benson, E Ahmed and C L Atkin

The Journal of experimental medicine, Vol.183(3), pp.1105-1110

03/01/1996

DOI: 10.1084/jem.183.3.1105

PMCID: PMC2192318

PMID: 8642252

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Abstract

Mycoplasma arthritidis, an agent of chronic proliferative arthritis of rodents, secretes a potent soluble superantigen, MAM, that is active for both murine and human T and B lymphocytes. We now report the complete nucleotide and amino acid sequence of MAM and show it to be distinct from other proteins and not closely related phylogenetically to other superantigens. Two functional domains on MAM are identified based on the ability of peptides encompassing these regions to inhibit lymphocyte proliferation by the intact MAM molecule. One of these domains shares short sequences or epitopes with other microbial superantigens. The second domain contains the consensus legume lectin motif- beta , which is important for T cell activation by concanavalin (Con) A. MAM and Con A peptides containing this motif are functionally cross reactive, suggesting a novel secondary pathway for T cell activation by MAM.

Mycoplasma arthritidis

Details

Title: Subtitle: The sequence of the Mycoplasma arthritidis superantigen, MAM: Identification functional domains and comparison with microbial superantigens and plant lectin mitogens
Creators: B Cole - University of Utah
K Knudtson - University of Utah
A Oliphant - University of Utah
A D Sawitzke - University of Utah
A Pole - University of Utah
M Manohar - University of Utah
L Benson
E Ahmed - University of Utah
C L Atkin - University of Utah
Resource Type: Journal article
Publication Details: The Journal of experimental medicine, Vol.183(3), pp.1105-1110
DOI: 10.1084/jem.183.3.1105
PMID: 8642252
PMCID: PMC2192318
ISSN: 0022-1007
eISSN: 1540-9538
Language: English
Date published: 03/01/1996
Academic Unit: Iowa Institute of Human Genetics
Record Identifier: 9984627348602771

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