Journal article
The shaping of invasive glioma phenotype by the ubiquitin-proteasome system
Cell communication & adhesion, Vol.20(5), pp.87-92
10/01/2013
DOI: 10.3109/15419061.2013.833192
PMID: 24004256
Abstract
Protein degradation is an indispensable process for cells which is often deregulated in various diseases, including malignant conditions. Depending on the specific cell type and functions of expressed proteins, this aberration may have different effects on the determination of malignant phenotypes. A discrete, inherent feature of malignant glioma is its profound invasive and migratory potential, regulated by the expression of signaling and effector proteins, many of which are also subjected to post-translational regulation by the ubiquitin-proteasome system (UPS). Here we provide an overview of this connection, focusing on important pro-invasive protein signals targeted by the UPS.
Details
- Title: Subtitle
- The shaping of invasive glioma phenotype by the ubiquitin-proteasome system
- Creators
- Panagiotis J. Vlachostergios - University of ThessalyIoannis A. Voutsadakis - Charmo UniversityChristos N. Papandreou - University of Thessaly
- Resource Type
- Journal article
- Publication Details
- Cell communication & adhesion, Vol.20(5), pp.87-92
- DOI
- 10.3109/15419061.2013.833192
- PMID
- 24004256
- NLM abbreviation
- Cell Commun Adhes
- ISSN
- 1541-9061
- eISSN
- 1543-5180
- Publisher
- Taylor & Francis
- Number of pages
- 6
- Language
- English
- Date published
- 10/01/2013
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806504802771
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