The skinny on obesity and plasma cell myeloma: a review of the literature

K R Carson; M L Bates; M H Tomasson

doi:10.1038/bmt.2014.71

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The skinny on obesity and plasma cell myeloma: a review of the literature

Journal article

Peer reviewed

The skinny on obesity and plasma cell myeloma: a review of the literature

K R Carson, M L Bates and M H Tomasson

Bone marrow transplantation (Basingstoke), Vol.49(8), pp.1009-1015

08/2014

DOI: 10.1038/bmt.2014.71

PMID: 24820216

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Abstract

Despite tremendous advances in treatments for myeloma in the past decade, the disease remains incurable in the majority of patients. Here, we review recent data demonstrating an association between obesity and increased risk of myeloma development. This may be due to the pro-inflammatory cytokine profile caused by obesity. Currently, there are no screening or prevention strategies for myeloma, but we propose that obesity-associated inflammatory pathways, or obesity itself, may be amenable to intervention, thereby preventing the transition from pre-malignancy to myeloma. In addition, we suggest that the morbidity, mortality and the significant costs associated with myeloma treatment could be reduced by addressing modifiable risk factors, and that research efforts should explore this novel hypothesis.

Multiple Myeloma - epidemiology

Precancerous Conditions - etiology

Multiple Myeloma - etiology

Precancerous Conditions - epidemiology

Obesity - complications

Humans

Obesity - epidemiology

Risk Factors

Precancerous Conditions - metabolism

Multiple Myeloma - metabolism

Obesity - metabolism

Details

Title: Subtitle: The skinny on obesity and plasma cell myeloma: a review of the literature
Creators: K R Carson - Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
M L Bates - Department of Pediatrics, Critical Care Division and the John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
M H Tomasson - Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
Resource Type: Journal article
Publication Details: Bone marrow transplantation (Basingstoke), Vol.49(8), pp.1009-1015
DOI: 10.1038/bmt.2014.71
PMID: 24820216
NLM abbreviation: Bone Marrow Transplant
ISSN: 0268-3369
eISSN: 1476-5365
Language: English
Date published: 08/2014
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center; Health, Sport, and Human Physiology ; Internal Medicine
Record Identifier: 9984094512002771

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