Journal article
The spatial chronnectome reveals a dynamic interplay between functional segregation and integration
Human brain mapping, Vol.40(10), pp.3058-3077
03/18/2019
DOI: 10.1002/hbm.24580
PMID: 30884018
Abstract
The brain is highly dynamic, reorganizing its activity at different interacting spatial and temporal scales, including variation within and between brain networks. The chronnectome is a model of the brain in which nodal activity and connectivity patterns change in fundamental and recurring ways over time. Most literature assumes fixed spatial nodes/networks, ignoring the possibility that spatial nodes/networks may vary in time. Here, we introduce an approach to calculate a spatially fluid chronnectome (called the spatial chronnectome for clarity), which focuses on the variations of networks coupling at the voxel level, and identify a novel set of spatially dynamic features. Results reveal transient spatially fluid interactions between intra- and internetwork relationships in which brain networks transiently merge and separate, emphasizing dynamic segregation and integration. Brain networks also exhibit distinct spatial patterns with unique temporal characteristics, potentially explaining a broad spectrum of inconsistencies in previous studies that assumed static networks. Moreover, we show anticorrelative connections to brain networks are transient as opposed to constant across the entire scan. Preliminary assessments using a multi-site dataset reveal the ability of the approach to obtain new information and nuanced alterations that remain undetected during static analysis. Patients with schizophrenia (SZ) display transient decreases in voxel-wise network coupling within visual and auditory networks, and higher intradomain coupling variability. In summary, the spatial chronnectome represents a new direction of research enabling the study of functional networks which are transient at the voxel level, and the identification of mechanisms for within- and between-subject spatial variability.
Details
- Title: Subtitle
- The spatial chronnectome reveals a dynamic interplay between functional segregation and integration
- Creators
- Armin Iraji - The Mind Research Network Albuquerque New MexicoThomas P Deramus - The Mind Research Network Albuquerque New MexicoNoah Lewis - The Mind Research Network Albuquerque New MexicoMaziar Yaesoubi - The Mind Research Network Albuquerque New MexicoJulia M Stephen - The Mind Research Network Albuquerque New MexicoErik Erhardt - Department of Mathematics and StatisticsUniversity of New Mexico Albuquerque New MexicoAysneil Belger - Department of PsychiatryUniversity of North Carolina Chapel Hill North CarolinaJudith M Ford - Department of PsychiatryUniversity of California San Francisco San Francisco California, Psychiatry Service, San Francisco VA Medical Center San Francisco CaliforniaSarah McEwen - Department of Psychiatry and Biobehavioral SciencesUniversity of California Los Angeles Los Angeles CaliforniaDaniel H Mathalon - Department of PsychiatryUniversity of California San Francisco San Francisco California, Psychiatry Service, San Francisco VA Medical Center San Francisco CaliforniaBryon A Mueller - Department of PsychiatryUniversity of Minnesota Minneapolis MinnesotaGodfrey D Pearlson - Department of PsychiatryYale University, School of Medicine New Haven ConnecticutSteven G Potkin - Department of Psychiatry and Human BehaviorUniversity of California Irvine Irvine CaliforniaAdrian Preda - Department of Psychiatry and Human BehaviorUniversity of California Irvine Irvine CaliforniaJessica A Turner - Department of PsychologyGeorgia State University Atlanta GeorgiaJatin G Vaidya - Department of PsychiatryUniversity of Iowa Iowa City IowaTheo G. M Erp - Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human BehaviorUniversity of California Irvine Irvine CaliforniaVince D Calhoun - The Mind Research Network Albuquerque New Mexico, Department of PsychiatryYale University, School of Medicine New Haven Connecticut, Department of Electrical and Computer EngineeringUniversity of New Mexico Albuquerque New Mexico
- Resource Type
- Journal article
- Publication Details
- Human brain mapping, Vol.40(10), pp.3058-3077
- DOI
- 10.1002/hbm.24580
- PMID
- 30884018
- NLM abbreviation
- Hum Brain Mapp
- ISSN
- 1065-9471
- eISSN
- 1097-0193
- Grant note
- DOI: 10.13039/100000025, name: National Institute of Mental Health, award: R01MH058262; DOI: 10.13039/100000002, name: National Institutes of Health, award: 2R01EB005846, P20GM103472, R01REB020407; DOI: 10.13039/100000001, name: National Science Foundation, award: 1539067; DOI: 10.13039/100000738, name: U.S. Department of Veterans Affairs, award: I01 CX0004971
- Language
- English
- Date published
- 03/18/2019
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute; University College Courses
- Record Identifier
- 9984004075502771
Metrics
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