Journal article
The structural and social determinants of Alzheimer's disease related dementias
Alzheimer's & dementia, Vol.19(7), pp.3171-3185
07/2023
DOI: 10.1002/alz.13027
PMCID: PMC10599200
PMID: 37074203
Abstract
The projected growth of Alzheimer's disease (AD) and AD-related dementia (ADRD) cases by midcentury has expanded the research field and impelled new lines of inquiry into structural and social determinants of health (S/SDOH) as fundamental drivers of disparities in AD/ADRD.
In this review, we employ Bronfenbrenner's ecological systems theory as a framework to posit how S/SDOH impact AD/ADRD risk and outcomes.
Bronfenbrenner defined the "macrosystem" as the realm of power (structural) systems that drive S/SDOH and that are the root cause of health disparities. These root causes have been discussed little to date in relation to AD/ADRD, and thus, macrosystem influences, such as racism, classism, sexism, and homophobia, are the emphasis in this paper.
Under Bronfenbrenner's macrosystem framework, we highlight key quantitative and qualitative studies linking S/SDOH with AD/ADRD, identify scientific gaps in the literature, and propose guidance for future research.
Ecological systems theory links structural/social determinants to AD/ADRD. Structural/social determinants accrue and interact over the life course to impact AD/ADRD. Macrosystem is made up of societal norms, beliefs, values, and practices (e.g., laws). Most macro-level determinants have been understudied in the AD/ADRD literature.
Details
- Title: Subtitle
- The structural and social determinants of Alzheimer's disease related dementias
- Creators
- Paris B Adkins-Jackson - Columbia UniversityKristen M George - University of California, DavisLilah M Besser - University of MiamiJinshil Hyun - Albert Einstein College of MedicineMelissa Lamar - Rush University Medical CenterTanisha G Hill-Jarrett - University of California, San FranciscoOmonigho M Bubu - New York UniversityJason D Flatt - University of Nevada, Las VegasPatricia C Heyn - Marymount UniversityEthan C Cicero - Emory UniversityA Zarina Kraal - Columbia UniversityPreeti Pushpalata Zanwar - NIA Funded Network on Life Course and Health Dynamics and Disparities, University of Southern California, Los Angeles, California, USARachel Peterson - University of MontanaBoeun Kim - Johns Hopkins UniversityRobert W Turner II - George Washington UniversityJaya Viswanathan - Bethesda, Maryland, USAErin R Kulick - Temple UniversityMegan Zuelsdorff - University of Wisconsin–MadisonShana D Stites - University of PennsylvaniaMiguel Arce Rentería - Columbia University Irving Medical CenterElena Tsoy - Global Brain Health InstituteDominika Seblova - Charles UniversityTed K S Ng - Arizona State UniversityJennifer J Manly - Columbia UniversityGanesh Babulal - Washington University in St. Louis
- Resource Type
- Journal article
- Publication Details
- Alzheimer's & dementia, Vol.19(7), pp.3171-3185
- DOI
- 10.1002/alz.13027
- PMID
- 37074203
- PMCID
- PMC10599200
- ISSN
- 1552-5260
- eISSN
- 1552-5279
- Grant note
- R01 AG052132 / NIA NIH HHS R24 AG065170 / NIA NIH HHS K23 AG065442 / NIA NIH HHS K01 AG054762 / NIA NIH HHS R03 AG063303 / NIA NIH HHS R01 NS119651 / NINDS NIH HHS R13 AG071313 / NIA NIH HHS K01 AG063895 / NIA NIH HHS K99 AG066932 / NIA NIH HHS R13 AG072884 / NIA NIH HHS
- Language
- English
- Date published
- 07/2023
- Academic Unit
- Nursing
- Record Identifier
- 9984701827102771
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