Journal article
The structure and expression of the human neuroligin- 3 gene
Gene, Vol.246(1), pp.303-310
2000
DOI: 10.1016/S0378-1119(00)00049-4
PMID: 10767552
Abstract
The neuroligins are a family of proteins that are thought to mediate cell to cell interactions between neurons. During the sequencing at an Xq13 locus associated with a mental retardation syndrome in some studies, we discovered a portion of the human orthologue of the rat
neuroligin-
3 gene. We now report the structure and the expression of that gene. The gene spans approximately 30
kb and contains eight exons. Unlike the rat gene, it codes for at least two mRNAs and at least one of which is expressed outside the CNS. Interestingly, the putative promoter for the gene overlaps the last exon of the neighboring HOPA gene and is located less than 1
kb from an OPA element in which a polymorphism associated with mental retardation is found. These findings suggest a possible role for the
neuroligin gene in mental retardation and that the role of the gene in humans may differ from its role in rats.
Details
- Title: Subtitle
- The structure and expression of the human neuroligin- 3 gene
- Creators
- Robert A Philibert - Department of Psychiatry, University of Iowa, Rm 2-126b Psychiatry Research/MEB, Iowa City, IA 52242-1000, USASuzanne L Winfield - Clinical Neuroscience Branch, National Institute of Mental Health, Building 49, Rm B1EE16, 49 Convent Drive, MSC 4405, Bethesda, MD 20892, USAHarinder K Sandhu - Department of Psychiatry, University of Iowa, Rm 2-126b Psychiatry Research/MEB, Iowa City, IA 52242-1000, USABrian M Martin - Clinical Neuroscience Branch, National Institute of Mental Health, Building 49, Rm B1EE16, 49 Convent Drive, MSC 4405, Bethesda, MD 20892, USAEdward I Ginns - Clinical Neuroscience Branch, National Institute of Mental Health, Building 49, Rm B1EE16, 49 Convent Drive, MSC 4405, Bethesda, MD 20892, USA
- Resource Type
- Journal article
- Publication Details
- Gene, Vol.246(1), pp.303-310
- DOI
- 10.1016/S0378-1119(00)00049-4
- PMID
- 10767552
- NLM abbreviation
- Gene
- ISSN
- 0378-1119
- eISSN
- 1879-0038
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 2000
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003951402771
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