The structure of Cryptococcus neoformans galactoxylomannan contains β- d-glucuronic acid

Christian Heiss; J Stacey Klutts; Zhirui Wang; Tamara L Doering; Parastoo Azadi

doi:10.1016/j.carres.2009.03.003

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The structure of Cryptococcus neoformans galactoxylomannan contains β- d-glucuronic acid

Journal article

Peer reviewed

The structure of Cryptococcus neoformans galactoxylomannan contains β- d-glucuronic acid

Christian Heiss, J Stacey Klutts, Zhirui Wang, Tamara L Doering and Parastoo Azadi

Carbohydrate research, Vol.344(7), pp.915-920

2009

DOI: 10.1016/j.carres.2009.03.003

PMID: 19345342

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Abstract

The structure of galactoxylomannan, a capsular polysaccharide from the opportunistic yeast Cryptococcus neoformans, was re-examined by NMR spectroscopy and GC–MS. The residue that is 3-linked to the side chain galactose and was previously assigned as β- d-xylose [Vaishnav, V. V.; Bacon, B. E.; O’Neill, M.; Cherniak, R. Carbohydr. Res. 1998, 306, 315–330] was determined to be β- d-glucuronic acid. A revised structure for this polymer is presented, along with a proposal that this compound be termed glucuronoxylomannogalactan (GXMGal).

GalXM

Polysaccharides, structure

Glucuronic acid

Cryptococcus neoformans

CPS

Details

Title: Subtitle: The structure of Cryptococcus neoformans galactoxylomannan contains β- d-glucuronic acid
Creators: Christian Heiss - Analytical Services/Complex Carbohydrate Research Center—University of Georgia, 315 Riverbend Road, Athens, GA 30602, United States
J Stacey Klutts - University of Iowa Carver College of Medicine and VA Medical Center, 601 Highway 6 West, Iowa City, IA 52246, United States
Zhirui Wang - Analytical Services/Complex Carbohydrate Research Center—University of Georgia, 315 Riverbend Road, Athens, GA 30602, United States
Tamara L Doering - Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, United States
Parastoo Azadi - Analytical Services/Complex Carbohydrate Research Center—University of Georgia, 315 Riverbend Road, Athens, GA 30602, United States
Resource Type: Journal article
Publication Details: Carbohydrate research, Vol.344(7), pp.915-920
Publisher: Elsevier Ltd
DOI: 10.1016/j.carres.2009.03.003
PMID: 19345342
ISSN: 0008-6215
eISSN: 1873-426X
Grant note: DOI: 10.13039/100000015, name: U.S. Department of Energy, award: DE-FG09-93ER-20097, R01 GM71007; DOI: 10.13039/100000002, name: National Institutes of Health, award: DE-FG09-93ER-20097, R01 GM71007
Language: English
Date published: 2009
Academic Unit: Pathology
Record Identifier: 9984047991402771

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