Journal article
The structure of LsrB from Yersinia pestis complexed with autoinducer-2
Acta crystallographica. Section F, Structural biology communications, Vol.67(12), pp.1501-1505
12/2011
DOI: 10.1107/S1744309111042953
PMCID: PMC3232125
PMID: 22139152
Abstract
The crystal structure of LsrB from Yersinia pestis complexed with autoinducer-2 (AI-2; space group P212121, unit-cell parameters a = 40.61, b = 61.03, c=125.23 angstrom) has been solved by molecular replacement using the structure of LsrB from Salmonella typhimurium (PDB entry ) and refined to R = 0.180 (Rfree = 0.213) at 1.75 angstrom resolution. The electron density for bound AI-2 and the stereochemistry of the AI-2-binding site are consistent with bound AI-2 adopting the (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran conformation, just as has been observed in the crystal structures of the Salmonella typhimurium and Sinorhizobium meliloti LsrBAI-2 complexes.
Details
- Title: Subtitle
- The structure of LsrB from Yersinia pestis complexed with autoinducer-2
- Creators
- Jeffrey S. Kavanaugh - University of IowaLokesh Gakhar - University of IowaAlexander R. Horswill - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Acta crystallographica. Section F, Structural biology communications, Vol.67(12), pp.1501-1505
- DOI
- 10.1107/S1744309111042953
- PMID
- 22139152
- PMCID
- PMC3232125
- NLM abbreviation
- Acta Crystallogr F Struct Biol Commun
- ISSN
- 1744-3091
- eISSN
- 2053-230X
- Publisher
- Int Union Crystallography
- Number of pages
- 5
- Grant note
- N00014-06-1-1176 / Office of Naval Research
- Language
- English
- Date published
- 12/2011
- Academic Unit
- Medicine Administration
- Record Identifier
- 9984622754502771
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