Journal article
The structure of a virus-encoded nucleosome
Nature structural & molecular biology, Vol.28(5), pp.413-417
05/2021
DOI: 10.1038/s41594-021-00585-7
PMCID: PMC8370576
PMID: 33927388
Abstract
Certain large DNA viruses, including those in the Marseilleviridae family, encode histones. Here we show that fused histone pairs Hβ-Hα and Hδ-Hγ from Marseillevirus are structurally analogous to the eukaryotic histone pairs H2B-H2A and H4-H3. These viral histones form 'forced' heterodimers, and a heterotetramer of four such heterodimers assembles DNA to form structures virtually identical to canonical eukaryotic nucleosomes.
Details
- Title: Subtitle
- The structure of a virus-encoded nucleosome
- Creators
- Marco Igor Valencia-Sánchez - Skirball Institute of Biomolecular Medicine, Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USAStephen Abini-Agbomson - Skirball Institute of Biomolecular Medicine, Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USAMiao Wang - Skirball Institute of Biomolecular Medicine, Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USARachel Lee - Skirball Institute of Biomolecular Medicine, Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USANikita Vasilyev - Howard Hughes Medical Institute, Chevy Chase, MD, USAJenny Zhang - Skirball Institute of Biomolecular Medicine, Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USAPablo De Ioannes - Skirball Institute of Biomolecular Medicine, Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USABernard La Scola - IHU Méditerranée Infection, Marseille, FrancePaul Talbert - Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USASteve Henikoff - Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USAEvgeny Nudler - Howard Hughes Medical Institute, Chevy Chase, MD, USAAlbert Erives - Department of Biology, University of Iowa, Iowa City, IA, USAKarim-Jean Armache - Skirball Institute of Biomolecular Medicine, Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA. karim-jean.armache@nyulangone.org
- Resource Type
- Journal article
- Publication Details
- Nature structural & molecular biology, Vol.28(5), pp.413-417
- DOI
- 10.1038/s41594-021-00585-7
- PMID
- 33927388
- PMCID
- PMC8370576
- NLM abbreviation
- Nat Struct Mol Biol
- ISSN
- 1545-9993
- eISSN
- 1545-9985
- Grant note
- P41 GM103310 / NIGMS NIH HHS S10 RR029300 / NCRR NIH HHS Howard Hughes Medical Institute R01 GM127267 / NIGMS NIH HHS S10 OD019994 / NIH HHS T32 GM088118 / NIGMS NIH HHS
- Language
- English
- Date published
- 05/2021
- Academic Unit
- Biology
- Record Identifier
- 9984217539102771
Metrics
29 Record Views