The study of cerebral ischemic reversibility: Part II. Preliminary preoperative results of fluoromethane positron emission tomographic determination of perfusion reserve in patients with carotid TIA and stroke

R L Levine; J J Sunderland; B R Rowe; R J Nickles

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Journal article

The study of cerebral ischemic reversibility: Part II. Preliminary preoperative results of fluoromethane positron emission tomographic determination of perfusion reserve in patients with carotid TIA and stroke

R L Levine, J J Sunderland, B R Rowe and R J Nickles

American journal of physiologic imaging, Vol.1(2), pp.104-114

1986

PMID: 3502524

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Abstract

Symmetries and asymmetries in regional cerebral blood flow (rCBF) determinations are reported in eleven patients with symptomatic carotid artery occlusive disease. Flourine-18-fluoromethane rCBF values are obtained by means of a noninvasive positron emission tomographic (PET) technique during room air (RA) and following induced hypercapnia (CO2). Areas of abnormal CO2 reactivity predict both the hemodynamic significance of the vascular lesion in question and the areas most vulnerable for ischemic infarction. This data is intended to be preliminary in nature; future expansions of this data base will be made to include rCBF/CO2 estimations, rCBF/glucose metabolism determinations, and rCBF/"reserve" evaluations over time and following brain-specific therapies. Once established, the potential viability and reversibility of these ischemic, uninfarcted or minimally infarcted areas can then be reestablished over time, thus providing a quantitative measure of the natural history of flow/metabolic coupling or uncoupling.

Cerebrovascular Disorders - physiopathology

Humans

Middle Aged

Carotid Artery Diseases - complications

Ischemic Attack, Transient - diagnostic imaging

Cerebrovascular Circulation

Hydrocarbons, Fluorinated

Ischemic Attack, Transient - etiology

Cerebrovascular Disorders - diagnostic imaging

Adult

Aged

Tomography, Emission-Computed

Fluorine Radioisotopes

Ischemic Attack, Transient - physiopathology

Details

Title: Subtitle: The study of cerebral ischemic reversibility: Part II. Preliminary preoperative results of fluoromethane positron emission tomographic determination of perfusion reserve in patients with carotid TIA and stroke
Creators: R L Levine - Department of Neurology, William S. Middleton Veterans Administration Hospital, Madison, Wisconsin 53705
J J Sunderland
B R Rowe
R J Nickles
Resource Type: Journal article
Publication Details: American journal of physiologic imaging, Vol.1(2), pp.104-114
Publisher: Denmark
PMID: 3502524
ISSN: 0885-8276
Language: English
Date published: 1986
Academic Unit: Radiology; Physics and Astronomy; Radiation Oncology
Record Identifier: 9984047855702771

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