Journal article
The synthesis of 13N-labelled nitrous oxide
The International journal of applied radiation and isotopes, Vol.29(4), pp.225-227
1978
DOI: 10.1016/0020-708X(78)90045-5
Abstract
A pair of methods is described for the synthesis of
13N
2O by pyrolysis of NH
4NO
3 in sulfuric acid. Both methods start with
13NO
3
− production via the proton irradiation of water. The methods differ in the use of precursor
13NO
3
− or
13NH
4
+ formed by nitrate reduction with DeVardas alloy. A 30% contamination with
13N
2 is common to both methods, but this falls to less than 2% when a ten-fold excess of NH
4
+ over
13NO
3
− is used. Millicurie activities of
13N
2O in 4 mM of carrier result from 18 min of processing with a decay-corrected yield of 80%. This yield encourages the use of
13N
2O as a positron-emitting tracer for the measurement of cerebral blood flow.
Details
- Title: Subtitle
- The synthesis of 13N-labelled nitrous oxide
- Creators
- R.J NicklesS.J GatleyR.D HichwaD.J SimpkinJ.L Martin
- Resource Type
- Journal article
- Publication Details
- The International journal of applied radiation and isotopes, Vol.29(4), pp.225-227
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0020-708X(78)90045-5
- ISSN
- 0020-708X
- Language
- English
- Date published
- 1978
- Academic Unit
- Radiology; Research Administration; Physics and Astronomy; Radiation Oncology
- Record Identifier
- 9984213290802771
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