Journal article
The synthesis of 18F-FDS and its potential application in molecular imaging
Molecular imaging and biology, Vol.10(2), pp.92-98
03/2008
DOI: 10.1007/s11307-007-0125-0
PMCID: PMC4143166
PMID: 18097725
Abstract
2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) is the most commonly used positron emission tomography (PET) tracer for oncological and neurological imaging, but it has limitations on detecting tumor or inflammation in brain gray matter. In this study, we describe the development of 2-deoxy-2-[(18)F]fluorosorbitol ((18)F-FDS) and its possible application in lesion detection around brain area.
(18)F-FDS was obtained by reduction of FDG using NaBH(4) (81 +/- 4% yield in 30 min). Cell uptake/efflux experiments in cell culture and small animal PET imaging on tumor and inflammation models were performed.
Despite the low accumulation in cell culture, (18)F-FDS had good tumor uptake and contrast in the subcutaneous U87MG tumor model (4.54%ID/g at 30 min post-injection). Minimal uptake in the normal mouse brain facilitated good tumor contrast in both U87MG and GL-26 orthotopic tumor models. (18)F-FDS also had increased uptake in the inflamed foci of the TPA-induced acute inflammation model.
Because of the ease of synthesis and favorable in vivo kinetics, (18)F-FDS may have potential applications in certain cases where FDG is inadequate (e.g., brain tumor).
Details
- Title: Subtitle
- The synthesis of 18F-FDS and its potential application in molecular imaging
- Creators
- Zi-Bo Li - Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, 1201 Welch Rd, P095, Stanford, CA 94305-5484, USAZhanhong Wu - Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, 1201 Welch Rd, P095, Stanford, CA 94305-5484, USAQizhen Cao - Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, 1201 Welch Rd, P095, Stanford, CA 94305-5484, USADavid W Dick - Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, 1201 Welch Rd, P095, Stanford, CA 94305-5484, USAJeffrey R Tseng - Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, 1201 Welch Rd, P095, Stanford, CA 94305-5484, USASanjiv S Gambhir - Department of Bioengineering, Stanford University School of Medicine, Stanford, CA, USAXiaoyuan Chen - Department of Bioengineering, Stanford University School of Medicine, Stanford, CA, USA
- Resource Type
- Journal article
- Publication Details
- Molecular imaging and biology, Vol.10(2), pp.92-98
- DOI
- 10.1007/s11307-007-0125-0
- PMID
- 18097725
- PMCID
- PMC4143166
- NLM abbreviation
- Mol Imaging Biol
- ISSN
- 1536-1632
- eISSN
- 1860-2002
- Publisher
- Springer Science and Business Media LLC; United States
- Grant note
- R21 CA102123 / NCI NIH HHS P50 CA114747 / NCI NIH HHS R01 CA119053 / NCI NIH HHS U54 CA119367 / NCI NIH HHS R21 CA121842 / NCI NIH HHS R24 CA93862 / NCI NIH HHS
- Language
- English
- Date published
- 03/2008
- Academic Unit
- Radiology; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984051754502771
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