Journal article
The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group
NPJ breast cancer, Vol.7, 150
12/01/2021
DOI: 10.1038/s41523-021-00346-1
PMCID: PMC8636568
PMID: 34853355
Abstract
The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with expression of programmed death-ligand 1 (PD-L1). These patients may potentially benefit from ICI targeting the programmed death 1 (PD-1)/PD-L1 signaling axis. The use of tumor-infiltrating lymphocytes (TILs) as predictive and prognostic biomarkers has been under intense examination. Emerging data suggest that TILs are associated with response to both cytotoxic treatments and immunotherapy, particularly for patients with triple-negative BC. In this review from The International Immuno-Oncology Biomarker Working Group, we discuss (a) the biological understanding of TILs, (b) their analytical and clinical validity and efforts toward the clinical utility in BC, and (c) the current status of PD-L1 and TIL testing across different continents, including experiences from low-to-middle-income countries, incorporating also the view of a patient advocate. This information will help set the stage for future approaches to optimize the understanding and clinical utilization of TIL analysis in patients with BC.
Details
- Title: Subtitle
- The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group
- Creators
- Khalid El Bairi - Mohamed I UniversityHarry R Haynes - University of BristolElizabeth Blackley - Peter MacCallum Cancer CentreSusan Fineberg - Albert Einstein College of MedicineJeffrey ShearSophia TurnerJuliana Ribeiro de Freitas - Universidade Federal da BahiaDaniel SurLuis Claudio AmendolaMasoumeh Gharib - Mashhad University of Medical SciencesInternational Immuno-Oncology Biomarker Working Group
- Contributors
- Andrew M Bellizzi (Contributor) - University of Iowa, Pathology
- Resource Type
- Journal article
- Publication Details
- NPJ breast cancer, Vol.7, 150
- DOI
- 10.1038/s41523-021-00346-1
- PMID
- 34853355
- PMCID
- PMC8636568
- NLM abbreviation
- NPJ Breast Cancer
- ISSN
- 2374-4677
- Language
- English
- Date published
- 12/01/2021
- Academic Unit
- Pathology
- Record Identifier
- 9984549160302771
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