Journal article
The tau mutation (val337met) disrupts cytoskeletal networks of microtubules
Neuroreport, Vol.10(5), pp.993-997
04/06/1999
DOI: 10.1097/00001756-199904060-00018
PMID: 10321473
Abstract
THE missense point mutation found in the tau gene, which was segregated in a family with frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), has proved to be the causal molecule for widely spread dementia diseases. Here we examined the effects of the tau mutation using confocal analysis. When wild-type tau cDNA was introduced into cells, extensive cell processes and well-developed thick bundles of microtubules were induced. On the other hand, when altered tau cDNA with the mutation (valine337-methionine) was introduced, cell lost processes and microtubule networks resulted in more round cell shape but showed intact mitochondria or endoplasmic reticulum. We conclude that the tau mutation primarily affects the microtubules and resultantly causes the loss of cellular organization and function due to microtubule disruption.
Details
- Title: Subtitle
- The tau mutation (val337met) disrupts cytoskeletal networks of microtubules
- Creators
- Shigeki Arawaka - 1Department of Neuroscience, Osaka City University Medical School, 1-4-3, Asahimachi, Abenoku, Osaka 545-8585, Japan 2Department of Molecular Biology, Tokyo Institute of Psychiatry, Setagayaku, Tokyo-156, Japan 3Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, WA 98195, USA 4Center for Neurologic Diseases, Brigham and Womenʼs Hospital, Harvard Medical School, Boston, MA 02115, USAMihoko UsamiNaruhiko SaharaGerry SchellenbergGloria LeeHiroshi Mori
- Resource Type
- Journal article
- Publication Details
- Neuroreport, Vol.10(5), pp.993-997
- Publisher
- Lippincott Williams & Wilkins, Inc
- DOI
- 10.1097/00001756-199904060-00018
- PMID
- 10321473
- ISSN
- 0959-4965
- eISSN
- 1473-558X
- Language
- English
- Date published
- 04/06/1999
- Academic Unit
- Iowa Neuroscience Institute; Immunology; Internal Medicine
- Record Identifier
- 9984065494902771
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