Journal article
The temporal evolution of structural and functional measures after acute optic neuritis
Journal of neurology, neurosurgery and psychiatry, Vol.86(12), pp.1369-1373
12/2015
DOI: 10.1136/jnnp-2014-309704
PMID: 25669747
Abstract
In this prospective case series, we aimed to characterise the temporal evolution of functional and structural measures in the afferent visual pathway of patients with acute optic neuritis (ON). Fifty patients with ON were followed over 12 months. Testing with spectral-domain optical coherence tomography, Early Treatment Diabetic Retinopathy Study logarithm of the minimum angle of resolution (LogMAR) visual acuity and Humphrey perimetry central 30-2 threshold (SITA strategy) was performed at baseline, 3, 6 and 12 months after symptom onset. The main outcome measure was mean peripapillary retinal nerve fibre layer (RNFL) thickness in ON eyes. Secondary outcomes included mean ganglion cell layer (GCL) thickness, LogMAR visual acuity, and Humphrey perimetry measured visual field mean deviation (VFMD). Survival analyses were performed to Kaplan-Meier curves and variables in the models were tested using the log-rank test. Over 12 months, RNFL and GCL values progressively declined in ON eyes, and intereye differences were significantly different across all time points. When functional recovery was defined as a VFMD better than -5.00 dB in ON eyes, the mean recovery time for the entire cohort was 3 months (survival was 48%, SE=0.09, 95% CI 0.30 to 0.64). There were significant differences in cumulative recovery when comparisons were made between genders: 3 months after symptom onset there was a higher percentage cumulative recovery for female (75%) versus male (25%) patients. Structural and functional measures evolve over time in patients with ON. There may be sex-specific differences in recovery after an acute ON event.
Details
- Title: Subtitle
- The temporal evolution of structural and functional measures after acute optic neuritis
- Creators
- Fiona Costello - Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada Department of Surgery, University of Calgary, Calgary, Alberta, Canada Hotchkiss Brain Institute, Calgary, Alberta, CanadaY Irene Pan - Department of Ophthalmology, University of Western Ontario, London, Ontario, CanadaE Ann Yeh - Division of Neurology, Hospital for Sick Children, Department of Pediatrics (Neurology), University of Toronto, Division of Neurosciences and Mental Health, SickKids Research InstituteWilliam Hodge - Department of Ophthalmology, University of Western Ontario, London, Ontario, CanadaJodie M Burton - Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada Hotchkiss Brain Institute, Calgary, Alberta, Canada Department of Community Health, University of Calgary, Calgary, Alberta, CanadaRandy Kardon - Department of Ophthalmology and Visual Science, University of Iowa, Department of Veterans Affairs Medical Center, Iowa City
- Resource Type
- Journal article
- Publication Details
- Journal of neurology, neurosurgery and psychiatry, Vol.86(12), pp.1369-1373
- DOI
- 10.1136/jnnp-2014-309704
- PMID
- 25669747
- NLM abbreviation
- J Neurol Neurosurg Psychiatry
- ISSN
- 0022-3050
- eISSN
- 1468-330X
- Publisher
- England
- Language
- English
- Date published
- 12/2015
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9983979989902771
Metrics
26 Record Views