Journal article
The tired hippocampus: the molecular impact of sleep deprivation on hippocampal function
Current opinion in neurobiology, Vol.44, pp.13-19
06/2017
DOI: 10.1016/j.conb.2017.02.005
PMCID: PMC5511071
PMID: 28242433
Abstract
Memory consolidation, the process by which information is stored following training, consists of synaptic consolidation and systems consolidation. It is widely acknowledged that sleep deprivation has a profound effect on synaptic consolidation, particularly for memories that require the hippocampus. It is unclear, however, which of the many molecular changes associated with sleep deprivation directly contribute to memory deficits. In this review, we highlight recent studies showing that sleep deprivation impairs hippocampal cAMP and mTOR signaling, and ultimately causes spine loss in CA1 neurons in a cofilin-dependent fashion. Reversing these molecular alterations made memory consolidation resistant to the negative impact of sleep deprivation. Together, these studies have started to identify the molecular underpinnings by which sleep deprivation impairs synaptic consolidation.
Details
- Title: Subtitle
- The tired hippocampus: the molecular impact of sleep deprivation on hippocampal function
- Creators
- Robbert Havekes - Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Groningen, The Netherlands. Electronic address: r.havekes@rug.nlTed Abel - Iowa Neuroscience Institute and Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. Electronic address: ted-abel@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Current opinion in neurobiology, Vol.44, pp.13-19
- Publisher
- England
- DOI
- 10.1016/j.conb.2017.02.005
- PMID
- 28242433
- PMCID
- PMC5511071
- ISSN
- 0959-4388
- eISSN
- 1873-6882
- Grant note
- P01 AG017628 / NIA NIH HHS R01 MH099544 / NIMH NIH HHS R21 MH102703 / NIMH NIH HHS
- Language
- English
- Date published
- 06/2017
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065733902771
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