Journal article
The transient receptor potential superfamily of ion channels
Journal of the American Society of Nephrology, Vol.15(7), pp.1690-1699
07/2004
DOI: 10.1097/01.ASN.0000129115.69395.65
PMID: 15213256
Abstract
The transient receptor potential (TRP) superfamily of proteins is cation-selective ion channels with six predicted transmembrane segments and intracellularly localized amino and carboxyl termini. Members of the TRP superfamily are identified on the basis of amino acid sequence and structural similarity and are classified into TRPC, TRPV, TRPM, TRPP, TRPN, and TRPML subfamilies. TRP channels are widespread and have diverse functions, ranging from thermal, tactile, taste, osmolar, and fluid flow sensing to transepithelial Ca2+ and Mg2+ transport. Mutations of TRP proteins produce many renal diseases, including Mg2+ wasting, hypocalcemia, and polycystic kidney diseases. This review focuses on recent advances in the understanding of their functions.
Details
- Title: Subtitle
- The transient receptor potential superfamily of ion channels
- Creators
- Chou-Long Huang - The University of Texas Southwestern Medical Center
- Resource Type
- Journal article
- Publication Details
- Journal of the American Society of Nephrology, Vol.15(7), pp.1690-1699
- DOI
- 10.1097/01.ASN.0000129115.69395.65
- PMID
- 15213256
- NLM abbreviation
- J Am Soc Nephrol
- ISSN
- 1046-6673
- eISSN
- 1533-3450
- Grant note
- DK-20543 / NIDDK NIH HHS DK-59530 / NIDDK NIH HHS DK-54368 / NIDDK NIH HHS
- Language
- English
- Date published
- 07/2004
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984359959402771
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