The use of acetazolamide in idiopathic intracranial hypertension during pregnancy

Andrew G Lee; Misha Pless; Julie Falardeau; Tammy Capozzoli; Michael Wall; Randy H Kardon

doi:10.1016/j.ajo.2004.12.091

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The use of acetazolamide in idiopathic intracranial hypertension during pregnancy

Journal article

Peer reviewed

The use of acetazolamide in idiopathic intracranial hypertension during pregnancy

Andrew G Lee, Misha Pless, Julie Falardeau, Tammy Capozzoli, Michael Wall and Randy H Kardon

American journal of ophthalmology, Vol.139(5), pp.855-859

05/2005

DOI: 10.1016/j.ajo.2004.12.091

PMID: 15860291

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Abstract

To describe the pregnancy outcomes after the use of acetazolamide in pregnant patients with idiopathic intracranial hypertension (IIH). Observational case series. setting: Two tertiary care academic neuro-ophthalmology units. patient population: Patients with IIH treated with acetazolamide. observation procedure: Documentation of pregnancy outcome. main outcome measures: Normal pregnancy, fetal loss, or congenital malformation. Twelve patients were treated with acetazolamide for IIH during pregnancy, and there were no adverse pregnancy outcomes. A critical review of the English language literature on the subject failed to demonstrate any convincing evidence for any adverse effect on pregnancy for acetazolamide. Acetazolamide at high doses may produce birth defects in animals, but there is little clinical or experimental evidence to support any adverse effect of the drug on pregnancy outcomes in humans. If the clinical situation warrants the use of acetazolamide in IIH, then the drug probably can be offered after appropriate informed consent.

Pregnancy

Pseudotumor Cerebri - drug therapy

Pregnancy Complications, Cardiovascular - drug therapy

Humans

Adult

Female

Retrospective Studies

Acetazolamide - therapeutic use

Pregnancy Outcome

Carbonic Anhydrase Inhibitors - therapeutic use

Details

Title: Subtitle: The use of acetazolamide in idiopathic intracranial hypertension during pregnancy
Creators: Andrew G Lee - Department of Ophthalmology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, PFP, Iowa City, IA 52242, USA. andrew-lee@uiowa.edu
Misha Pless
Julie Falardeau
Tammy Capozzoli
Michael Wall
Randy H Kardon
Resource Type: Journal article
Publication Details: American journal of ophthalmology, Vol.139(5), pp.855-859
DOI: 10.1016/j.ajo.2004.12.091
PMID: 15860291
NLM abbreviation: Am J Ophthalmol
ISSN: 0002-9394
eISSN: 1879-1891
Publisher: United States
Language: English
Date published: 05/2005
Academic Unit: Neurology; Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
Record Identifier: 9983980280802771

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