Journal article
The use of immunohistochemistry in detection of perineural invasion in mucoepidermoid carcinoma
Oral surgery, oral medicine, oral pathology and oral radiology, Vol.121(6), pp.636-642
06/2016
DOI: 10.1016/j.oooo.2016.01.026
PMID: 27068680
Abstract
To retrospectively study the prevalence of perineural invasion (PNI) in cases of mucoepidermoid carcinoma (MEC). The study evaluated if previously assessed PNI would be increased by re-review of the original hematoxylin and eosin-stained (H&E) slides and also review of slides reacted immunohistochemically with S100 to enhance nerve visualization and whether this is associated with clinical outcome.
Thirty-one cases were reviewed for PNI with H&E-stained slides as well as S-100-reacted slides. These results were compared with the original pathology report's PNI status when available (13 of 31). Subject demographic characteristics and clinical outcome were collected from electronic medical records.
PNI was identified in 23% (3 of 13) of tumors in the original reports, 13% (4 of 31) of the authors' re-review of the slides, and 29% (9 of 31) by immunohistochemical assessment for S100. PNI and larger-diameter nerve involvement were significantly associated with death at 5-year follow-up.
Immunohistochemical assessment for S100 improves the accuracy of PNI determination. PNI is a significant factor in the survival outcome of cases of MEC.
Details
- Title: Subtitle
- The use of immunohistochemistry in detection of perineural invasion in mucoepidermoid carcinoma
- Creators
- Emily Lanzel - College of Dentistry, University of Iowa, Iowa City, Iowa, USA. Electronic address: Emily-Lanzel@uiowa.eduRobert A Robinson - Department of Pathology, The Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USAMiriam Bridget Zimmerman - Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, USAAli Pourian - College of Dental Medicine, Roseman University of Health Sciences, South Jordan, Utah, USAJohn W Hellstein - College of Dentistry, University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Oral surgery, oral medicine, oral pathology and oral radiology, Vol.121(6), pp.636-642
- Publisher
- United States
- DOI
- 10.1016/j.oooo.2016.01.026
- PMID
- 27068680
- ISSN
- 2212-4403
- eISSN
- 2212-4411
- Language
- English
- Date published
- 06/2016
- Academic Unit
- Oral Pathology, Radiology and Medicine; Pathology; Biostatistics
- Record Identifier
- 9983997450902771
Metrics
15 Record Views