Journal article
The utility of PU.1 as an immunohistochemical marker for histiocytic and dendritic lesions of the skin
The American journal of dermatopathology, Vol.31(5), pp.432-435
07/2009
DOI: 10.1097/DAD.0b013e31818866a7
PMID: 19542915
Abstract
PU.1 is a transcription factor restricted to the hematopoietic system. It is expressed in myeloid lineage and B lymphocytes but is absent in mature T cells and nonhematopoietic cells. Among myeloid lineage-derived cells, PU.1 is overexpressed in monocytes, histiocytes, and dendritic cells. We evaluated PU.1 expression in 78 cases of primary skin neoplasms, including 9 reticulohistiocytomas, 9 Langerhans cell histiocytoses, 7 juvenile xanthogranulomas, 9 fibrous papules, 8 dermatofibromas, 12 dermatofibrosarcoma protuberans, 9 Spitz nevi, and 15 malignant melanomas. Strong nuclear staining for PU.1 was seen in all cases of histiocyte and dendritic cell origin, including 9/9 reticulohistiocytomas, 9/9 Langerhans cell histiocytoses, and 7/7 juvenile xanthogranulomas. No staining for PU.1 was seen in any studied cases of fibrous papules, dermatofibrosarcoma protuberans, dermatofibromas, Spitz nevi, or malignant melanomas. This study indicates that PU.1 is a valuable immunohistochemical marker for identifying cutaneous histiocyte- and dendritic cell-derived lesions. PU.1 staining is easily interpreted due to the sharp nuclear staining as compared with the irregular and often variable cytoplasmic staining seen with CD68.
Details
- Title: Subtitle
- The utility of PU.1 as an immunohistochemical marker for histiocytic and dendritic lesions of the skin
- Creators
- DesiRae Muirhead - Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USAMary Seabury StoneSergei I Syrbu
- Resource Type
- Journal article
- Publication Details
- The American journal of dermatopathology, Vol.31(5), pp.432-435
- Publisher
- United States
- DOI
- 10.1097/DAD.0b013e31818866a7
- PMID
- 19542915
- ISSN
- 0193-1091
- eISSN
- 1533-0311
- Language
- English
- Date published
- 07/2009
- Academic Unit
- Dermatology; Pathology
- Record Identifier
- 9984047603502771
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