Journal article
The utility of albuterol nebulized with heliox during acute asthma exacerbations
American journal of respiratory and critical care medicine, Vol.165(9), pp.1317-1321
2002
DOI: 10.1164/rccm.9907035
PMID: 11991886
Abstract
Heliox improves lung deposition of inhaled particles when compared with air or oxygen inhalation. We studied the spirometric effects of albuterol nebulized with heliox during emergency room visits for asthma exacerbations. Forty-five patients were randomized to receive albuterol nebulized with oxygen (control) versus heliox (n = 22 control and 23 heliox subjects). At baseline, demographics, outpatient asthma medications, vital signs, oxygen saturation, and forced expiratory volume in one second were not different between the two groups. Three consecutive albuterol treatments were given to each group. The heliox group had a significantly higher heart rate after albuterol nebulization compared with the control group. Following albuterol Treatment 1, the median change in forced expiratory volume in one second was 14.6% in the control group and 32.4% in the heliox group (p = 0.007). After Treatment 2, the results were 22.7% versus 51.5%, respectively (p = 0.007). After Treatment 3, the results were 26.6% versus 65.1%, respectively (p = 0.016). We conclude that during acute asthma exacerbations, albuterol nebulized with heliox leads to a more significant improvement in spirometry when compared with albuterol nebulized with oxygen. This is likely due to the low-density gas improving albuterol deposition in the distal airways.
Details
- Title: Subtitle
- The utility of albuterol nebulized with heliox during acute asthma exacerbations
- Creators
- John P KRESS - Department of Medicine, University of Chicago, Chicago, Illinois, United StatesImre NOTH - Department of Medicine, University of Chicago, Chicago, Illinois, United StatesBrian K GEHLBACH - Department of Medicine, University of Chicago, Chicago, Illinois, United StatesNitin BARMAN - Department of Medicine, University of Chicago, Chicago, Illinois, United StatesAnne S POHLMAN - Department of Medicine, University of Chicago, Chicago, Illinois, United StatesAnnette MILLER - Department of Medicine, University of Chicago, Chicago, Illinois, United StatesSherwin MORGAN - Department of Medicine, University of Chicago, Chicago, Illinois, United StatesJesse B HALL - Department of Medicine, University of Chicago, Chicago, Illinois, United States
- Resource Type
- Journal article
- Publication Details
- American journal of respiratory and critical care medicine, Vol.165(9), pp.1317-1321
- Publisher
- American Lung Association; New York, NY
- DOI
- 10.1164/rccm.9907035
- PMID
- 11991886
- ISSN
- 1073-449X
- eISSN
- 1535-4970
- Language
- English
- Date published
- 2002
- Academic Unit
- Neurology; Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984020630002771
Metrics
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