Journal article
The vagal ganglia transcriptome identifies candidate therapeutics for airway hyperreactivity
American journal of physiology. Lung cellular and molecular physiology, Vol.315(2), pp.L133-L148
Translational Physiology
08/01/2018
DOI: 10.1152/ajplung.00557.2017
PMCID: PMC6139658
PMID: 29631359
Abstract
Mainstay therapeutics are ineffective in some people with asthma, suggesting a need for additional agents. In the current study, we used vagal ganglia transcriptome profiling and connectivity mapping to identify compounds beneficial for alleviating airway hyperreactivity (AHR). As a comparison, we also used previously published transcriptome data from sensitized mouse lungs and human asthmatic endobronchial biopsies. All transcriptomes revealed agents beneficial for mitigating AHR; however, only the vagal ganglia transcriptome identified agents used clinically to treat asthma (flunisolide, isoetarine). We also tested one compound identified by vagal ganglia transcriptome profiling that had not previously been linked to asthma and found that it had bronchodilator effects in both mouse and pig airways. These data suggest that transcriptome profiling of the vagal ganglia might be a novel strategy to identify potential asthma therapeutics.
Details
- Title: Subtitle
- The vagal ganglia transcriptome identifies candidate therapeutics for airway hyperreactivity
- Creators
- Leah R Reznikov - Department of Physiological SciencesDavid K Meyerholz - Department of PathologyMahmoud Abou Alaiwa - Department of Internal MedicineShin-Ping Kuan - Department of Physiological SciencesYan-Shin J Liao - Department of Physiological SciencesNicholas L Bormann - Department of Internal MedicineThomas B Bair - Iowa Institute of Human GeneticsMargaret Price - Department of Internal MedicineDavid A Stoltz - Department of Internal MedicineMichael J Welsh - Department of Internal Medicine
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Lung cellular and molecular physiology, Vol.315(2), pp.L133-L148
- Series
- Translational Physiology
- DOI
- 10.1152/ajplung.00557.2017
- PMID
- 29631359
- PMCID
- PMC6139658
- NLM abbreviation
- Am J Physiol Lung Cell Mol Physiol
- ISSN
- 1040-0605
- eISSN
- 1522-1504
- Publisher
- American Physiological Society; Bethesda, MD
- Grant note
- ; 10T2TR001983-01 / ; 1K99HL119560-01A1; 4R00HL119560-03; 1P01HL091842 / ;
- Alternative title
- CANDIDATE THERAPEUTICS FOR AIRWAY HYPERREACTIVITY
- Language
- English
- Date published
- 08/01/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Pathology; Neurosurgery; Internal Medicine
- Record Identifier
- 9984025471002771
Metrics
27 Record Views