Journal article
The value of blood cytokines and chemokines in assessing COPD
Respiratory research, Vol.18(1), pp.180-180
2017
DOI: 10.1186/s12931-017-0662-2
PMCID: PMC5655820
PMID: 29065892
Abstract
Background: Blood biomarkers are increasingly used to stratify high risk chronic obstructive pulmonary disease (COPD) patients; however, there are fewer studies that have investigated multiple biomarkers and replicated in multiple large well-characterized cohorts of susceptible current and former smokers.
Methods: We used two MSD multiplex panels to measure 9 cytokines and chemokines in 2123 subjects from COPDGene and 1117 subjects from SPIROMICS. These biomarkers included: interleukin (IL)-2, IL-6, IL-8, IL-10, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, eotaxin/CCL-11, eotaxin-3/CCL-26, and thymus and activation-regulated chemokine (TARC)/CCL-17. Regression models adjusted for clinical covariates were used to determine which biomarkers were associated with the following COPD phenotypes: airflow obstruction (forced expiratory flow at 1 s (FEV1%) and FEV1/forced vital capacity (FEV1/FVC), chronic bronchitis, COPD exacerbations, and emphysema. Biomarker-genotype associations were assessed by genome-wide association of single nucleotide polymorphisms (SNPs).
Results: Eotaxin and IL-6 were strongly associated with airflow obstruction and accounted for 3-5% of the measurement variance on top of clinical variables. IL-6 was associated with progressive airflow obstruction over 5 years and both IL-6 and IL-8 were associated with progressive emphysema over 5 years. None of the biomarkers were consistently associated with chronic bronchitis or COPD exacerbations. We identified one novel SNP (rs9302690 SNP) that was associated with CCL17 plasma measurements.
Conclusion: When assessing smoking related pulmonary disease, biomarkers of inflammation such as IL-2, IL-6, IL-8, and eotaxin may add additional modest predictive value on top of clinical variables alone.
Trial registration: COPDGene (ClinicalTrials.gov Identifier: NCT02445183 ). Subpopulations and Intermediate Outcomes Measures in COPD Study (SPIROMICS) ( ClinicalTrials.gov Identifier: NCT 01969344 ).
Trial registration: ClinicalTrials.gov NCT02445183 NCT01969344.
Details
- Title: Subtitle
- The value of blood cytokines and chemokines in assessing COPD
- Creators
- Eric Bradford - 1400 Jackson St., K715, Denver, CO 80206 USASean Jacobson - 1400 Jackson St., K715, Denver, CO 80206 USAJason Varasteh - 1400 Jackson St., K715, Denver, CO 80206 USAAlejandro P Comellas - 200 Hawkins Dr C331-GH, Iowa City, IA 52242 USAPrescott Woodruff - Box 0130, Rm HSE 1305, 513 Parnassus Ave, San Francisco, CA 94143 USAWanda O’Neal - Chapel Hill, NC USADawn L DeMeo - Boston, Massachusetts USAXingnan Li - Tucson, AZ USAVictor Kim - 785 Parkinson Pavilion, 3401 North Broad Street, Philadelphia, PA 19140 USAMichael Cho - Channing Division of Network Medicine and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115 USAPeter J Castaldi - Boston, Massachusetts USACraig Hersh - Boston, Massachusetts USAEdwin K Silverman - Channing Division of Network Medicine and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115 USAJames D Crapo - 1400 Jackson St., K715, Denver, CO 80206 USAKaterina Kechris - Mail Stop B119, 13001 E. 17th Place, Aurora, CO 80045 USARussell P Bowler - 1400 Jackson St., K715, Denver, CO 80206 USA
- Resource Type
- Journal article
- Publication Details
- Respiratory research, Vol.18(1), pp.180-180
- DOI
- 10.1186/s12931-017-0662-2
- PMID
- 29065892
- PMCID
- PMC5655820
- NLM abbreviation
- Respir Res
- ISSN
- 1465-9921
- eISSN
- 1465-993X
- Publisher
- BioMed Central
- Grant note
- HL089897 and HL089856; HHSN268200900013C, HHSN268200900014C, HHSN268200900015C, HHSN268200900016C, HHSN268200900017C, HHSN268200900018C HHSN268200900019C, HHSN268200900020C / ;
- Language
- English
- Date published
- 2017
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; ICTS; Internal Medicine
- Record Identifier
- 9984094712202771
Metrics
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