Journal article
The value of diffusion weighted imaging and apparent diffusion coefficient in primary Osteogenic and Ewing sarcomas for the monitoring of response to treatment: Initial experience
European journal of radiology, Vol.124, pp.108855-108855
03/2020
DOI: 10.1016/j.ejrad.2020.108855
PMID: 32018075
Abstract
•ADC can reflect cellular changes associated with chemotherapy use in Ewing and Osteosarcoma.•Quantitative use of ADC is not adequate to dictate change in management or chemotherapy dose.•There was no difference in ADC or volumetric measurements between good and poor responders.
To assess the value of using Apparent Diffusion Coefficient (ADC) mapping in Diffusion Weighted Imaging (DWI) when monitoring treatment response in pediatric Osteogenic and Ewing sarcomas and to correlate with level of necrosis on post-surgical excision pathology.
This retrospective study includes 7 Osteosarcoma and 8 Ewing sarcoma patients. Pre-treatment and post-treatment focal MRIs were evaluated for ADC values, tumor volumes and variability of both measurements. We also compared the measurement between Ewing and Osteosarcoma groups, as well as between good (=/>90 % necrosis post-excision) and poor (<90 % necrosis post-excision) responders.
All measurements except Maximum ADC (p = 0.20) showed a statistically significant difference when comparing them before and after treatment. When we segregated our population according to pathologic complete response, there was no difference in ADC measurements, volumetric measurements or either variability between good (8 Patients) and poor responders (7 Patients). When comparing the before-after changes in our measurement between the Ewing sarcoma and Osteosarcoma cases, there was no significant difference in the change between pre and post treatment (Δ) Mean or Maximum ADC, or in Δtumor-volume when measured on STIR or SPIR T1 post-contrast sequences. Only the ΔMinimum-ADC showed a statistically significant difference (p < 0.02) in this group.
ADC can potentially reflect cellular changes associated with chemotherapy use, reflecting a response to treatment. However, quantitative use of those parameters to dictate a change in management, treatment regimen or chemotherapy dose in order to target a good response (>/ = 90 % necrosis post-excision) needs further investigation.
Details
- Title: Subtitle
- The value of diffusion weighted imaging and apparent diffusion coefficient in primary Osteogenic and Ewing sarcomas for the monitoring of response to treatment: Initial experience
- Creators
- Karl Asmar - American University of Beirut Medical CenterCharbel Saade - American University of BeirutRida Salman - American University of BeirutRaya Saab - American University of BeirutNabil J. Khoury - American University of BeirutMiguel Abboud - American University of Beirut Medical CenterHani Tamim - American University of BeirutMaha Makki - American University of Beirut Medical CenterLena Naffaa - American University of Beirut
- Resource Type
- Journal article
- Publication Details
- European journal of radiology, Vol.124, pp.108855-108855
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.ejrad.2020.108855
- PMID
- 32018075
- ISSN
- 0720-048X
- eISSN
- 1872-7727
- Language
- English
- Date published
- 03/2020
- Academic Unit
- Radiology
- Record Identifier
- 9984697722602771
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